Chemistry of Chiral Pharmaceuticals
- Authors: Anirudh Singh Bhathiwal1, Allu Udayasri2, Anjaneyulu Bendi3
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View Affiliations Hide Affiliations1 Department of Chemistry, MMV, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India 2 Department of Chemistry, Aditya Institute of Technology and Management, Tekkali-532201, Andhra Pradesh, India 3 Department of Chemistry, Kalinga University, Kotni, Near Mantralaya, New Raipur-492101, Chhattisgarh, India
- Source: The Role of Asymmetric Synthesis in Drug Discovery , pp 198-218
- Publication Date: December 2025
- Language: English
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The chapter gives an insight into the chemistry of chiral pharmaceuticals, discussing the different classes of compounds that have been synthesized using asymmetric methods. It covers the synthetic routes used to produce chiral pharmaceuticals and discusses the impact of chirality on their pharmacological properties. The chapter discusses key challenges in developing enantioselective syntheses for complex drug molecules, particularly those with intricate structures and multiple stereo-enters. It examines issues like controlling stereoselectivity, optimizing reaction conditions, and scaling up for industrial use. Additionally, the chapter explores the biological activities of chiral heterocycles, emphasizing how their stereochemistry impacts drug potency, selectivity, and metabolism. It highlights both the importance of enantioselective synthesis and the critical role of chiral heterocycles in the effectiveness of modern pharmaceuticals.
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