Asymmetric Synthesis of Medicinally Important Dihydropyrimidinones
- Authors: Rajni Sharma1, Taruna Yadav2, Anjaneyulu Bendi3
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View Affiliations Hide Affiliations1 Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurugram122505, Haryana, India 2 Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurugram122505, Haryana, India 3 Department of Chemistry, Kalinga University, Kotni, Near Mantralaya, New Raipur 492101, Chhattisgarh, India
- Source: The Role of Asymmetric Synthesis in Drug Discovery , pp 74-95
- Publication Date: December 2025
- Language: English
Asymmetric Synthesis of Medicinally Important Dihydropyrimidinones, Page 1 of 1
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The Biginelli reaction is considered one of the well-known examples of a multicomponent reaction that is useful in the synthesis of dihydropyrimidinones (DHPMs) using aryl aldehydes, urea, and esters and these are significant compounds in medicinal chemistry and chemical synthesis. DHPMs are considered vital compounds due to their diverse biological functions. Because of their remarkable and concentrated target-oriented biological activity, DHPMs have been the subject of large-scale and extensive research in the past few decades to determine how to synthesize them by using various catalysts and structural variations in a variety of solvents. Ionic liquids, Lewis acids, and organocatalysts are some of the chiral catalysts used in the enantioselective Biginelli reaction. This book chapter summarizes chiral reagents for asymmetric synthesis with particular absolute configuration.
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