Asymmetric Synthesis of Pharmacologically Active Spirooxindoles
- Authors: Chanchal Vashisth1, Prabhjot Kaur2, Urmila Berar3, Neera Raghav4
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View Affiliations Hide Affiliations1 Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana 136119, India 2 Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana-136119, India 3 Institute of Engineering and Technology, Kurukshetra University, Kurukshetra, Haryana136119, India 4 Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana-136119, India
- Source: The Role of Asymmetric Synthesis in Drug Discovery , pp 47-73
- Publication Date: December 2025
- Language: English
Asymmetric Synthesis of Pharmacologically Active Spirooxindoles, Page 1 of 1
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Spirooxindoles are a class of organic compounds characterized by a spirocyclic framework, where an oxindole moiety (which is a structure containing an indole fused to a carbonyl group) is connected to another ring system via a spiro carbon atom. These compounds have attracted significant interest in medicinal chemistry due to their diverse biological activities. They have been studied for their potential as anticancer, anti-inflammatory, and antimicrobial agents. The structural diversity of spirooxindoles allows for a wide range of pharmacological activities, making them valuable scaffolds in drug design. This chapter compiles the recent synthetic schemes on asymmetric synthesis of spirooxindoles and their significance as potential drug candidates. It discusses the different synthetic routes used to prepare chiral spirooxindoles and highlights the impact of chirality on their biological activities.
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