On the Trail of Zika Virus: Understanding its Druggable Targets
- Authors: Leandro Rocha Silva1, Edeildo Ferreira da Silva-Júnior2
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View Affiliations Hide Affiliations1 Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Lourival Melo Mota Avenue, 57072 970, Maceió, Brazil 2 Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Lourival Melo Mota Avenue, 57072-970, Maceió, Brazil
- Source: Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases , pp 268-300
- Publication Date: August 2025
- Language: English
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The Zika virus (ZIKV) is responsible for the infection of millions of people, causing mild flu-like symptoms and even severe symptoms, which are related to the nervous system, including Guillain-Barré syndrome and microcephaly. Nonetheless, it still remains with no antiviral treatments or effective vaccine to prevent it. Thus, several efforts have been addressed to discover a medicinal alternative to disrupt the ZIKV infection worldwide. Notwithstanding these facts, this chapter will focus on the main antiviral targets associated with ZIKV and their inhibitors identified so far. In principle, viral and host factors related to the ZIKV life cycle could be targeted for the development of novel drugs. In fact, there are some macromolecular targets that could be further investigated aiming to develop anti-ZIKV drugs, some of which remain still a few explored. In summary, this chapter encourages the exploration of new opportunities for medicinal chemists to design novel anti-ZIKV agents, providing a solid hope for future treatments against this disease.
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