Chagas Diseases: State of the Art and New Perspectives
- Authors: Gioele Renzi1, Silvia Selleri2, Claudiu T. Supuran3, Fabrizio Carta4
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View Affiliations Hide Affiliations1 Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze FI, Sesto Fiorentino, Italy 2 Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze FI, Sesto Fiorentino, Italy 3 Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze FI, Sesto Fiorentino, Italy 4 Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze FI, Sesto Fiorentino, Italy
- Source: Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases , pp 92-124
- Publication Date: August 2025
- Language: English
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American trypanosomiasis, also known as Chagas Disease (CD), is a Neglected Tropical Disease (NTD) of the infectious type, having the protozoan parasite Trypanosoma cruzi (T. cruzi) as the etiologic agent. The CD is usually transmitted to human hosts by means of the Triatomine bug bites, and it is endemic in regions characterized by substandard environmental conditions, such as Central and South America. The globalization of goods and people significantly contributed to spreading CD to regions not previously affected and/or not adequate for the proliferation of transmitting bugs. This chapter reviews the main features of the disease, its main symptoms, the actual therapies, and the most advanced, although not for clinical use and currently considered for further development.
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