Advancements in Antileishmanial Drug Discovery: Targeting Druggable Pathways and Overcoming Treatment Challenges
- Authors: Salma Darwish1, Mohamed Teleb2, Sherry N. Nasralla3, Sherine N. Khattab4, Adnan A. Bekhit5
-
View Affiliations Hide Affiliations1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt 3 Pharmacy Program, Allied Health Department, College of Health and Sport Sciences, University of Bahrain, Sakhir 32038, Kingdom of Bahrain 4 Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt
- Source: Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases , pp 46-91
- Publication Date: August 2025
- Language: English
Advancements in Antileishmanial Drug Discovery: Targeting Druggable Pathways and Overcoming Treatment Challenges, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9789815324785/chapter-2-1.gif
Over the last decades, neglected tropical diseases (NTDs), especially leishmaniasis, have been the focus of several drug discovery programs. The identification of the pathogen druggable targets and the ability to map the differences between parasites and human enzymes have contributed to the increased interest in the development of new lead compounds. Despite this progress, there remain substantial gaps with respect to developing efficient medications that can be the foundation for surmounting the acquired resistance and overcoming treatment failure. With this background in mind, this chapter will discuss the validated drug targets with a special focus on the reported structural determinants of activity of novel antileishmanial agents. The aim is to introduce an updated overview of the medicinal chemistry aspects of leishmaniasis to the scientific community.
-
From This Site
/content/books/9789815324785.chapter-2dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
