The Role of Gut Microbiota in Ocular Diseases
- Authors: Tapas Kumar Roy1, Arnab Roy2, Swati Bairagya3, Sanjay Dey4
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View Affiliations Hide Affiliations1 Department of Ocular Pharmacology and Pharmacy Division, Dr. R.P.Centre, AIIMS, New Delhi, India 2 Department of Biological Sciences (Pharmacology and Toxicology), National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India 3 Department of Pharmacology/Biotechnology, Delhi Pharmaceutical Sciences and Research University, New Delhi, India 4 Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, Barasat Barrackpore Road, Kolkata 700126, West Bengal, India
- Source: Gut Microbiota and their Impact on Disease Pathways and Interventions , pp 140-165
- Publication Date: April 2025
- Language: English
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The adaptive environment that is crucial to the host's health is the microbiome. Several research works have revealed that dysbiosis, or changes in the gut microbiota of humans can have an involvement in the etiology of a number of prevalent ailments, including diabetes, cancer, and neuropsychiatric disorders. Nonetheless, recent findings indicate the potential for a gut-eye axis, in which gut dysbiosis suggests a crucial role in the progression and development of an array of ocular conditions, that include uveitis, diabetic retinopathy, glaucoma and age-related macular degeneration. Current therapeutic strategies include probiotic and prebiotic supplementation, which seems to be the most economical and practical way to avoid ocular diseases and return the gut microbiome to a healthy state. In this chapter, we discuss the present understanding of gut dysbiosis linked with the pathophysiology of common eye disorders along with potential therapeutic implications for future translational studies in this research area.
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