Protocol for an Ocular Pharmacokinetic Study in Rabbits for an Ocular Anti-hypertensive Drug

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Ocular pharmacokinetics (PK) is an essential component of drug research and development, leading to the understanding of drug or drug candidate absorption, distribution, and elimination firstly in tissues targeted for efficacy and secondly in tissues/fluids that may be relevant to off-target effects (e.g., toxicity). Rabbits are one species of choice for ocular PK due to greater eye size relative to rodents and lower expense relative to dogs or monkeys, as well as the wealth of published ocular PK data (and use in regulatory submissions). This chapter describes a generic protocol for assessing ocular PK for glaucoma and anterior eye segment research. The collection procedure is detailed but will vary depending on the objective of the PK study or the lab performing the study. As such, this is one, albeit relatively common, approach one can consider for studying ocular PK in rabbits.