Protocol for Inducing IOP-Elevation (OHT) Using Hypertonic Saline Injection into Episcleral Veins of Rats
- By Shahid Husain1
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View Affiliations Hide Affiliations1 Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, 167 Ashley Ave, Charleston, SC 29425, USA
- Source: Research Protocols for Ophthalmic Disease Mechanisms and Therapeutics: Glaucoma - Ocular Hypertension , pp 297-302
- Publication Date: August 2025
- Language: English
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This chapter provides a description of protocols utilized to develop ocular hypertension (OHT) in rats via episcleral/limbal veins occlusion using hypertonic saline injections. A procedure for measuring the elevated intraocular pressure (IOP) using a TonoLab rebound tonometer in these animals is also described. Furthermore, the impact of the raised IOP on retinal ganglion cell (RGC) function in this model of OHT/glaucoma, using pattern electroretinograms (Pattern ERG) as a measure of RGC function, is detailed.
Hardbound ISBN:
9789815324341
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9789815324334
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