Recent Advances in the Synthesis of O- and S-Glycosides from Glycals
- Authors: Mittali Maheshwari1, Bindu Tiwari2, Manish Kumar Sharma3, Nazar Hussain4
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View Affiliations Hide Affiliations1 Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India 2 Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India 3 Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India 4 Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India
- Source: Glycals and their Derivatives , pp 24-68
- Publication Date: February 2025
- Language: English
Recent Advances in the Synthesis of O- and S-Glycosides from Glycals, Page 1 of 1
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Approximately 20 to 30 percent of all natural drugs are glycosylated, and the attached carbohydrate unit is pivotal for their biological activity. O- and S-glycosides constitute a significant portion of various biologically potent molecules and natural products. The synthesis of O- and S-glycosides holds immense importance due to several medicinal benefits. This chapter explores several methodologies for accessing O- and S-glycosides and the subsequent utilization of these glycosides for oligosaccharide generation. Specific pathways involved in O- and S-glycosides synthesis are discussed, along with detailed consideration of factors influencing the stereoselectivity of the desired products.
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