Antimicrobial Properties of Eugenol in Euphorbia Species from Mexican Arid Zones
- Authors: Axel Rodrigo Molina Gallardo1, Carlos Castillo-Hernández2, Julieta Orozco-Martínez3, Israel Valencia Quiroz4, Claudia Tzasna Hernández-Delgado5
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View Affiliations Hide Affiliations1 Laboratory of Natural Products Bioactivity, UBIPRO, Superior Studies Faculty (FES)-Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla de Baz, Mexico State-54090, Mexico 2 Laboratory of Natural Products Bioactivity, UBIPRO, Superior Studies Faculty (FES)-Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla de Baz, Mexico State-54090, Mexico 3 Laboratory of Natural Products Bioactivity, UBIPRO, Superior Studies Faculty (FES)-Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla de Baz, Mexico State-54090, Mexico 4 Phytochemistry Laboratory, UBIPRO, Superior Studies Faculty (FES)-Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla de Baz, Mexico State-54090, Mexico 5 Laboratory of Natural Products Bioactivity, UBIPRO, Superior Studies Faculty (FES)-Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla de Baz, Mexico State-54090, Mexico
- Source: Arid and Semi-Arid Zones of Mexico: A Comprehensive Exploration of Biodiversity, Ecology, and Conservation , pp 220-238
- Publication Date: June 2025
- Language: English
Antimicrobial Properties of Eugenol in Euphorbia Species from Mexican Arid Zones, Page 1 of 1
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Owing to its privileged biogeographical location, Mexico has an incomparable wealth with other regions of the world. This location has allowed for the development of various ecosystems, and drylands have been particularly important for plant diversity. Within this taxonomic richness, the family Euphorbiaceae has been highlighted due to its ecological and medicinal importance. This chapter explores the antibacterial properties of eugenol. It has been reported that this compound is present in some Euphorbia species, focusing on its antimicrobial activity in performed experiments. Comprehensive research has been conducted on this compound regarding its antimicrobial, anti-inflammatory, antioxidant, and anticancer properties. In this study, eugenol showed potential activity against microbial infections; it also showed activity for avoiding the development of biofilms and an increase in antimicrobial resistance when used in combination with antibiotics. In this case, the tested antibiotics were cefuroxime and cefepime. Previous studies have shown that eugenol, when combined with antibiotics, can produce sensitivity in Staphylococcus aureus-resistant strains, producing a significant reduction of the minimum inhibitory concentration (MIC). The MIC value was found to be between 125 and 1000 µg/mL. Eugenol can also initiate the apoptosis process and stop the cellular cycle process; in this regard, it was also found that eugenol at relatively low concentrations can inhibit the synthesis of biofilms in the evaluated microorganisms. This chapter details the characteristics and plant diversity of arid areas in Mexico, examines the traditional uses of Euphorbia in medicine, and highlights the potential medical benefits of its extracts and secondary metabolites, as well as some pharmacological properties of eugenol. More research is needed to understand the safety and efficacy of Euphorbia products given their diversity and endemism in Mexico.
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