Nanoparticle-Mediated Delivery of RNA-Based Therapeutics for Colon Cancer: Current Status and Future Prospects

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Colon cancer is a leading cause of cancer-related mortality globally, and the available treatment options are often limited in their effectiveness. RNA-based therapeutics hold promise as a novel approach for treating colon cancer. However, the delivery of these therapeutics to cancer cells poses significant challenges. Nanoparticles have emerged as a potential solution for the targeted delivery of RNAbased therapeutics to colon cancer cells. This chapter provides a comprehensive review of the development of nanoparticles specifically designed for the delivery of RNAbased therapeutics in the context of colon cancer. The chapter highlights the advantages offered by nanoparticle-based delivery systems, such as improved stability, protection against degradation, and extended circulation time. Various types of nanoparticles utilized for RNA delivery are discussed, including lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles. The challenges associated with nanoparticle-based delivery, such as potential immunogenicity and toxicity, are also addressed, emphasizing the need for further refinement and optimization. In conclusion, the development of nanoparticle-based delivery systems holds significant promise in overcoming the challenges associated with the delivery of RNA-based therapeutics for colon cancer. This chapter provides a comprehensive overview of the current state of research in this field and offers insights into future directions for advancing nanoparticle-based delivery strategies in colon cancer therapy.