Enzymatic Targets for Drug Discovery Against Alzheimer's Disease
- Authors: Ahmet Ozan Ozgen1, Ozan Emre Eyupoglu2
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View Affiliations Hide Affiliations1 Department of Medicinal Biotechnology, Akdeniz University, Antalya Turkey 2 Department of Biochemistry, School of Pharmacy, Istanbul Medipol University, Istanbul Turkey
- Source: Enzymatic Targets for Drug Discovery Against Alzheimer's Disease , pp 121-158
- Publication Date: December 2023
- Language: English
Enzymatic Targets for Drug Discovery Against Alzheimer's Disease, Page 1 of 1
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Alzheimers Disease (AD) is a neurodegenerative disease. The disease itself is progressive and full recovery from it isnt achievable yet. There are several hypotheses asserted (Cholinergic hypothesis, Amyloid hypothesis etc.) to explain the mechanisms behind the disease. Also, many targets have been identified for possible therapeutics and from these targets, numerous drug candidates have been evaluated in clinical trials. Unfortunately, most of these trials failed due to the enigmatic nature of this disease. Currently, there are 7103 targets associated with Alzheimer's disease listed in the Open Targets platform where 1240 of them are enzyme-related. In this chapter, enzymatic targets of the AD have been reviewed, and those claimed to have disease modifying effects were selected and presented according to their clinical significance.<br>
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