Memantine and Glutamate Antagonists in the Treatment of Alzheimer's Disease: Current Updates
- Authors: Rakesh Kore1, Priya Tiwari2, Vijay K Patel3, Ekta Shirbhate4, Ravichandran Veerasamy5, Achal Mishra6, Harish Rajak7
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View Affiliations Hide Affiliations1 Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur 495 009, (C.G.) India 2 Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C.G.) India 3 Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C.G.) India 4 Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C.G.) India 5 Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman Malaysia 6 Faculty of Pharmaceutical Sciences, Shri Shankaracharya Group of Institutions, Junwani, Bhiali (CG) India 7 Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C.G.) India
- Source: Enzymatic Targets for Drug Discovery Against Alzheimer's Disease , pp 111-120
- Publication Date: December 2023
- Language: English
Memantine and Glutamate Antagonists in the Treatment of Alzheimer's Disease: Current Updates, Page 1 of 1
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Alzheimers disease (AD) is the most important cause of dementia and a complex chronic neurodegenerative disease. Many of the currently marketed drugs are used to treat this disease condition, but a major issue with these drugs is their neurotoxicity. Alzheimer's treatment with the FDA approval of memantine resolves the neurotoxicity issue. Memantine acts on glutamate and its receptors in the treatment of AD. Recent studies show that NMDA receptor-acting drugs are doing well in the healing of Alzheimer's patients, because of their selectivity on receptor and neuroprotective activity. The present work is an attempt to collect updated information about memantine and glutamate antagonists used for the treatment of AD. <br>
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