Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
- Authors: Paolo Guglielmi1, Virginia Pontecorvi2, Atilla Akdemir3
-
View Affiliations Hide Affiliations1 Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185Rome, Italy 2 Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy 3 Computer aided Drug Discovery Laboratory, Department of Pharmacology, Bezmialem Vakif University, Fatih, Istanbul 34093, Turkey
- Source: Flavonoids and Phenolics , pp 272-297
- Publication Date: November 2022
- Language: English
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9789815079098/chapter-9-1.gif
Continuous efforts in the development of monoamine oxidase inhibitors prompted the search for effective strategies for the design of novel drugs candidate. Thankfully, nature often provides scaffolds useful for the promotion of novel exploitable chemical entities. In this regard, aurones (a class of uncommon flavonoids) and their structural related analogues may play an important role in the development of monoamine oxidase inhibitors. The target prediction of the simplest aurone (2- benzylidenebenzofuran-3(2H)-one) clearly suggests that this compound probably affects MAO (monoamine oxidase) enzymes, which is in accordance with the recently reported literature. The current chapter reports the recent discoveries involving aurones and their structurally related analogues as MAO inhibitors, describing detailed structure-activity relationships (SARs) for each subgroup of compounds.
-
From This Site
/content/books/9789815079098.chapter-9dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
