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Recent Progress on Natural and Synthetic Flavanone and its Derivatives

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Flavanones with various biological and pharmacological activities which result from their unique structure, a chiral center at C2 and a single bond between C2- C3, are considered as a special subgroup of flavonoids. These naturally occurring compounds with anticancer, antibacterial, anti-inflammatory activity, as well as building blocks and intermediates for organic synthesis have attracted organic and medicinal chemists’ attention. Widespread and at the same time interesting application of flavanones in different fields of chemistry and pharmacology, reveals increasing interests in their syntheses from different synthetic methods. In addition, there are many articles published every year about natural flavanones and their novel derivatives from different natural sources and study of their biological activities is also proof of their priority. As a result, herein we have studied recent progresses about flavanones from different aspects such as their: various synthetic methods, different derivatives, biological activities, natural sources reported in articles from 2015 to late 2020.

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