Beyond the Synthetic Drugs: Fungal Endophytes Derived Bioactive Compounds in the Management of Neurodegenerative Disorders
- Authors: Ashish Verma1, Nilesh Rai2, Swapnil C. Kamble3, Pradeep Mishra4, Suvakanta Barik5, Rajiv Kumar6, Santosh Kumar Singh7, Prafull Salvi8, Vibhav Gautam9
-
View Affiliations Hide Affiliations1 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India 2 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India 3 Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007, India 4 Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77-Stockholm, Sweden 5 Chemical Engineering Discipline, Indian Institute of Technology Gandhinagar, Gujarat-382355, India 6 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India 7 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India 8 Department of Agriculture Biotechnology, National Agri-Food Biotechnology Institute, SAS Nagar, Mohali, Punjab-140306, India 9 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India
- Source: Traditional Medicine for Neuronal Health , pp 82-102
- Publication Date: March 2023
- Language: English
Beyond the Synthetic Drugs: Fungal Endophytes Derived Bioactive Compounds in the Management of Neurodegenerative Disorders, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9789815040197/chap4-1.gif
Fungal endophytes are a group of fungi that reside in plant tissues and show a symbiotic relationship with the host plants. They protect against pathogens and increase food availability without causing any harmful effects on the host plant. Fungal endophytes are known to produce a wide range of bioactive compounds with several biological activities, including neuroprotective effects. Neurodegenerative disorders lead to miscommunication between nerve cells, damage or loss in structure and function of the central nervous system (CNS) or peripheral nervous system (PNS). Reactive oxygen species, neuroinflammation, protein degradation or aggregation, familial history, mutation in mitochondrial genes, and aging contribute to neurodegenerative disorders. Plant-associated fungal endophytes produce bioactive compounds, which show anti-neuroinflammatory, antioxidant, and anti-cholinesterase activities. Several pro-inflammatory (TNF-α and NF-κB) and depressant (serotonin, dopamine, and noradrenaline) molecules or neuronal signaling pathways leading to neurodegenerative disorders are known to be inhibited or down-regulated by fungal endophyte-derived bioactive compounds. Therefore, bioactive compounds produced from fungal endophytes could be a promising approach to treating various health nbsp;ailments. The present chapter discusses selected fungal endophyte-derived potential bioactive compounds with neuroprotective effects for managing neurodegenerative disorders.
-
From This Site
/content/books/9789815040197.chap4dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
