Modulations of SIRTUINs and Management of Brain Disorders
- Authors: Sudhir Kumar Shekhar1, Sarfraj Ahmad Siddiqui2, Girish Rai3
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View Affiliations Hide Affiliations1 Department of Biochemistry, King George Medical University, Lucknow 226003 (U.P.), India 2 Department of Zoology, University of Lucknow, Lucknow-226007 (U.P.), India 3 Vivekanand Government PG College Maihar, Manpur- 485771 (M.P.), India
- Source: Traditional Medicine for Neuronal Health , pp 47-81
- Publication Date: March 2023
- Language: English
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Neurodegenerative disorders are the conditions in which neurons of the central and peripheral nervous systems degenerate. Various cellular and molecular processes are associated with the progression of such degeneration, including inflammation, apoptosis, and axonal degeneration. Recently, SIRTUINs have emerged as one of the key factors associated with neurodegenerative disorders. SIRTUINs are involved in the regulation of several cellular and molecular processes in neurons of the nervous system through the deacetylation of target proteins. The chapter focuses on the modulatory role of SIRTUINs in neurodegenerative disorders and their potential therapeutic application. nbsp;
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