Optimised Voltammetric Approaches for Clinical Sample Analysis
- Authors: Gnanesh Rao1, Raghu Ningegowda2, B. P. Nandeshwarappa3, Kiran Kumar Mudnakudu-Nagaraju4, M. B Siddesh5, Sandeep Chandrashekharappa6
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View Affiliations Hide Affiliations1 Department of Biochemistry, Bangalore University, Bangalore, Karnataka, India 2 Jyoti Nivas College Autonomous, Department of Studies in Chemistry, Bangalore 560095, India 3 Department of PG Studies and Research in Chemistry, Shivagangothri, Davangere University, Davanagere, Karnataka - 577 007, India 4 Department of Biotechnology & Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysore 570015, Karnataka, India 5 Department of Chemistry, KLE'S S. K. Arts College and H. S. K. Science Institute, Hubballi, Karnataka 580031, India 6 Institute for Stem Cell Science and Regenerative Medicine, NCBS, TIFR, GKVK-Campus Bellary road, Bengaluru 560065, Karnataka, India ⋅ Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, Lucknow (UP)-226002, India
- Source: Voltammetry for Sensing Applications , pp 158-176
- Publication Date: February 2022
- Language: English
Optimised Voltammetric Approaches for Clinical Sample Analysis, Page 1 of 1
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Extraordinary properties of nanomaterial lay a broad prospect for itsapplication in various fields. Biosensors are a kind of special sensor which consists ofbiomolecule recognition element and transducer. Advances in biosensors with the useof micro/ nanomaterials are capable of detecting and analyzing living and chemicalmatter with high specificity, fastness, sensitivity, accuracy and low cost for thedetermination of proteins, hormone, enzyme, nucleic acid and other biologicalcompounds in blood and urine samples. The basics of biosensors and optimizedapproaches for voltammetric clinical analysis are studied in this chapter. Exosomes aresmall extracellular vesicles (EV) involved in extracellular communication betweencells, and are recognized as potential markers of human health and diseases. Anextensive molecular characteristic comparison of the exosomal components of healthyand disordered cells or tissues reveals the differences. Electrochemical approaches for the analysis of clinical samples are developing at anincredible rate with advances in nanotubes and nanomaterials as biosensors. Exosomes play a crucial role in cell-to-cell communication in normal health anddisease. They are potential biomarkers exploited for emerging non-invasive diagnosis. CNT sensors are capable of precise quantitative and qualitative detection of analytes.
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