Structure-Activity Relationship of Flavonoids: Recent Updates

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<div&gt;The biological, physicochemical, and environmental properties of&lt;/div&gt;<div&gt;substances are anticipated by utilizing structure-activity relationships (SARs). A SAR&lt;/div&gt;<div&gt;is a (qualitative) correlation between a chemical substructure and the potential for one&lt;/div&gt;<div&gt;of the chemicals in the substructure to have a particular biological property or effect.</div&gt;<div&gt;We are familiar with the term SAR which is a powerful concept in the discovery of any&lt;/div&gt;<div&gt;active pharmaceutical ingredient with both qualitative and quantitative associations that&lt;/div&gt;<div&gt;relate to the chemical structure and biological activity of any chemical compound. Due&lt;/div&gt;<div&gt;to their safety and medicinal efficacy, plant-derived functional foods are of great&lt;/div&gt;<div&gt;interest. In this chapter, the different types of biologically active compounds, their&lt;/div&gt;<div&gt;chemistry and SAR, and the different biologically active compounds from daily dietary&lt;/div&gt;<div&gt;supplements, foods, and fruits, which contain polyphenolic compounds, have been&lt;/div&gt;<div&gt;discussed. SAR of flavonoids like anthocyanidins, which is the principal component of&lt;/div&gt;<div&gt;the majority of fruits, vegetables, and flower petals, flavonols, usually called catechins,</div&gt;<div&gt;and isoflavones, are also discussed. Other polyphenolic compounds like tannins with&lt;/div&gt;<div&gt;their subtypes like hydrolysable and non-hydrolysable tannins are well covered.</div&gt;