Beta Glucan For The Treatment Of Recurrent Aphthous Stomatitis And Diabetic Ulcers

Recurrent Aphthous Stomatitis (RAS), which has symptoms like pain while eating, speaking, or swallowing, is one of the most hurtful oral mucosal inflammatory ulcerative diseases [1]. Tumor necrosis factor α (TNF α), has a main role in predominantly cell-mediated immune response due to the pathogenesis of RAS. The aim of this study was to investigate the therapeutic effects of Beta-glucan on the response of lymphocytes with and without phytohemagglutinin (PHA), a T lymphocyte mitogen, in treatment of RAS. RAS, estimated by the Ulcer Severity Score (USS), shows ulcer characteristics (number, size, duration, ulcer-free period, site, and pain).