The Chemistry of Ynamide and Its Application in Organic Synthesis
- Authors: Siyu Ye, Na Wu2
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View Affiliations Hide Affiliations2 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China
- Source: Advances in Organic Synthesis: Volume 13 , pp 52-170
- Publication Date: November 2020
- Language: English
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Ynamide, is an understudied but attractive class of alkynes, activated by the donating ability of the nitrogen adjacent to alkynes. With the nucleophilicity on β- carbon and the electrophilicity on α-carbon of ynamides, this review summarizes the syntheses of ynamides and miscellaneous reactions - oxidation, rearrangement, cyclization, and cycloaddition to construct complicated heterocyclic rings. The synthetic methodologies were further applied into natural products synthesis, e.g. marinoquinolines A and C, aplidiopsamine A, rigidin A, and 7-azaserotonin derivative.
Hardbound ISBN:
9789811405082
Ebook ISBN:
9789811405099
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