Role of aluminium in Post-Translational Modifications and Neurological Disorders
- Authors: Saadia Zahid1, Sanila Amber2, Fatima Javed Mirza3
-
View Affiliations Hide Affiliations1 Neurobiology Laboratory, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan 2 Neurobiology Laboratory, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan 3 Neurobiology Laboratory, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan
- Source: Biochemical Mechanisms of Aluminium Induced Neurological Disorders , pp 66-80
- Publication Date: December 2021
- Language: English
Role of aluminium in Post-Translational Modifications and Neurological Disorders, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781681088839/chapter-3-1.gif
Increased exposure or elevated levels of aluminium(Al) in humans cause various detrimental pathological processes especially affecting the central nervous system. Al-induced neurotoxicity predominantly leads to impaired motor coordination, cognition and learning and memory deficits. Significant association of chronic Al exposure with several neurological disorders, including Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS) Parkinson's disease (PD) and multiple sclerosis (MS) is evident where it instigates aberrant expression of various proteins via alterations in post-translational modifications (PTMs). In depth understanding of mechanism of action of Al, effect of altered PTMs and their detection methods is essential to revert anomalies induced by Al in these neurological disorders. The present chapter will attempt to summarize the role of Al in modulation of significant PTMs including phosphorylation, methylation, oxidation, ubiquitination and provide insights into its involvement in various neurological disorders.
-
From This Site
/content/books/9781681088839.chapter-3dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
