Polymeric Nanoparticles for Drug Delivery to the Brain
- Authors: Silvia Vasiliu1, Cristina D. Vlad2, Stefania Racovita3, Maria Andreea Lungan4, Lucian Eva5, Raluca Munteanu6
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View Affiliations Hide Affiliations1 “Petru Poni” Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley no. 41A, 700487, Iasi, Romania 2 “Petru Poni” Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley no. 41A, 700487, Iasi, Romania 3 “Petru Poni” Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley no. 41A, 700487, Iasi, Romania 4 “Gheorghe Asachi” Technical University of Iaşi, Faculty of Chemical Engineering and Environmental Protection Department of Natural and Synthetic Polymers, Prof. dr. docent Dimitrie Mangeron Str., no. 73, 700050, Iaşi, Romania 5 “Prof. Dr. Nicolae Oblu” Clinical Emergency Hospital, Neurosurgery Section, Ateneului Str., no. 2, 700309, Iasi, Romania 6 “Prof. Dr. Nicolae Oblu” Clinical Emergency Hospital, Neurosurgery Section, Ateneului Str., no. 2, 700309, Iasi, Romania
- Source: Polymeric Nanomedicines , pp 340-411
- Publication Date: May 2013
- Language: English
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The brain is the most complex and remarkable organ in the human body because it is responsible for memories, movement, feelings, intelligence, emotions and desires determining the uniqueness of each person. This organ is protected against various harmful substances due to the presence of two types of barriers: the blood-brain barrier and the blood cerebrospinal fluid barrier. The blood-brain barrier is an important limiting factor for the development of new drugs that can be delivered to the central nervous system. For this reason different approaches have been developed in order to overcome this barrier. Polymeric nanoparticles represent one of the most stimulating challenges for the scientific world, being investigated as drug delivery systems for effective systemic and local delivery of therapeutics to the central nervous system. This chapter presents in introduction a classification of the central nervous diseases followed by a presentation of different strategies that have been developed in order to obtain the polymeric nanoparticles as well as their applications for treatment and prevention of some central nervous diseases.
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