Placental Disorders in Preeclampsia: Maternal and Perinatal Outcomes
- Authors: Dave Lanoix1,2, Sophie Haché4,5, Evemie Dubé7,8, Julie Lafond10,11, Cathy Vaillancourt12,13,14
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View Affiliations Hide Affiliations1 INRS Institut Armand-Frappier, Universit du Qubec, 531 blvd. des Prairies, Laval, QC, Canada, H7V 1B7, Canada 2 BioMed Research Centre, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 4 BioMed Research Centre, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 5 Department of Sciences Biologiques, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 7 BioMed Research Centre, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 8 Department of Sciences Biologiques, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 10 BioMed Research Centre, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 11 Department of Sciences Biologiques, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada 12 BioMed Research Centre 13 INRS-Institut Armand-Frappier, Universit du Qubec, 531 blvd. des Prairies, Laval, QC, Canada, H7V1B7 14 BioMed Research Centre, Universit du Qubec Montral, C.P. 8888, Succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada
- Source: Pregnancy Disorders and Perinatal Outcomes , pp 97-128
- Publication Date: June 2012
- Language: English
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Preeclampsia, a disorder of pregnancy, is a leading cause of maternal and infant illness and death affecting about 3-15 % of all pregnancies worldwide. It is characterized by high blood pressure and the presence of protein in the urine. It originates in the placenta and causes variable maternal and fetal problems. At its worst, it may threaten maternal and perinatal survival. Preeclampsia is defined as a syndrome (a pattern of clinical features) and is probably heterogeneous in its origin as it is in its presentation. To date, the only complete cure known for preeclampsia is delivery, accompanied by the removal of the placenta. As the complete etiology of preeclampsia is still unknown, researches are crucial in order to know more about this pathophysiology and to develop different treatments and prediction approaches. This chapter focuses on current knowledge and recent discoveries on preeclampsia, especially on the role of placenta in its physiopathology. The chapter also presents current knowledge concerning preeclampsia diagnosis, epidemiology, risk factors and pathogenesis with an emphasis on maternal and perinatal outcomes related to this most common cause of death for both children and mothers during pregnancy.
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