Gestational Diabetes Affects Placental-Fetal Development
- Authors: Evemie Dubé1,2, Cathy Vaillancourt3,4, Julie Lafond5,6, Louiza Belkacemi7
-
View Affiliations Hide Affiliations1 Department of Sciences Biologiques, Universit du Qubec Montral, Montral, Qubec, Canada 2 BioMed Research Centre, Montral, Qubec, Canada 3 BioMed Research Centre, Montral, Qubec, Canada 4 INRS-Institut Armand-Frappier, Laval,Qubec, Canada 5 Department of Sciences Biologiques, Universit du Qubec ? Montral, Montral, Qubec, Canada, H3C 3P8, Canada 6 BioMed Research Centre, Montral, Qubec, Canada 7 Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Los AngelesBiomedical Research Institute at Harbor-UCLA, and David Geffen School of Medicine at UCLA, Torrance,California 90502, USA
- Source: Pregnancy Disorders and Perinatal Outcomes , pp 88-96
- Publication Date: June 2012
- Language: English
Gestational Diabetes Affects Placental-Fetal Development, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781608053728/chapter-6-1.gif
Gestational diabetes mellitus occurs only during pregnancy, and usually disappears shortly after delivery. Although, GDM is a common disorder, its pathophysiology is not well understood. Impaired placental function is probably a contributing factor as the placenta hinders insulin signaling and produce increased levels of cytokines that affect placental transport and metabolism of glucose and lipids. This in turn negatively impacts on fetal growth and development with significantly increased risk of a number of short-and long-term adverse consequences for the fetus, and the most significant of which is a predisposition to the development of metabolic syndrome and Type 2 diabetes. This article will describe placental changes in gestational diabetes related to glucose and lipids following placental insulin and cytokines dysfunction, and subsequent effects on the offspring development.
-
From This Site
/content/books/9781608053728.chapter-6dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
