Nature as Source and Inspiration for the Synthesis of New Anticancer Drugs

- Authors: Daniele Passarella, Alessandra Giardini, Giordano Lesma, Alessandra Silvani, Bruno Danieli5
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View Affiliations Hide Affiliations5 Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, Via Venezian, 21 20133 Milano, Italy
- Source: Frontiers in Natural Product Chemistry: Volume 1 , pp 51-54
- Publication Date: January 2005
- Language: English
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The bifunctional taxoid-colchicinoid hybrids were synthesised and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity.
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