Bentham Science Publishers

This is the fourth volume of the eBook Series entitled Topics in Anti-Cancer Research. This volume covers new research as well as updated chapters on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery.

Interesting diverse methods, new technologies and fast developing areas in the field of anti-cancer research are presented. The topics included in the present volume will be of great value to clinicians, scientists and R&D experts aiming to learn more about the latest developments and new alternatives for different types of cancer treatment.

The use of gold macro rods and ultrasound for cancer treatment with hyperthermia, obesity associated breast cancer, and the role of cytokines and chemokines pathways in studying cancer immunotherapy are discussed. The mechanism of antibody-drug and antibody-toxin conjugates alongwith clinical trials research, significance of transforming growth factor-beta and urokinase type plasminogen activator in tumorigenesis and reverstol studies in oncohematological disorders are also presented.

Other important areas covered include the discovery of novel compounds, drugs and chemotherapeutics in the treatment of lung cancer, biological functions of cell surface nucleolin in cancer, polymeric nanosystems and nanosystem applications used for anticancer drug therapy. Recent advances in development of new potent tubulin inhibitors and structures of molecular hybrids and their actions in different cell lines have also been discussed. All these studies focused are supported by recent associated patents

The topics covered in this fourth volume will be of immense interest for those researchers and scientists looking for new techniques, targets, drugs, compounds and drug delivery methods for various types of cancer and its control.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research. The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel

drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer

compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies

targeting cancer stem cells for the treatment of different types of cancers, including myeloma

and renal cell cancer.

The diversity of researches and topics published in this eBook Series will be valuable to

cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer

targets for the treatment of various cancers.

The topics covered in the eighth volume of this series are as follows:

-Novel Drugs for Multiple Myeloma

-Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs

-Recent Progress of Phenazines as Anticancer Agents

-Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges

Topological geometrodynamics (TGD) is a modification of the theory of general relativity inspired by the problems related to the definition of inertial and gravitational energies in the earlier hypotheses. TGD is also a generalization of super string models. TGD brings forth an elegant theoretical projection of reality and builds upon the work by renowned scientists (Wheeler, Feynman, Penrose, Einstein, Josephson to name a few).

In TGD, Physical space-time planes are visualized as four-dimensional surfaces in a certain 8-dimensional space (H). The choice of H is fixed by symmetries of standard model and leads to a geometric mapping of known classical fields and elementary particle numbers. TGD differs from Einstein's geometrodynamics in the way space-time planes or ‘sheets' are lumped together. Extending the theory based on fusing number concepts implies a further generalisation of the space-time concept allowing the identification of space-time correlates of cognition and intentionality.

Additionally, zero energy ontology forces an extension of quantum measurement theory to a theory of consciousness and a hierarchy of phases is identified. Dark matter is thus predicted with far reaching implications for the understanding of consciousness and living systems. Therefore, it sets a solid foundation for modeling our universe in geometric terms.

Topological Geometrodynamics: An Overview explains basic and advanced concepts about TGD. The book covers introductory information and classical TGD concepts before delving into twistor-space theory, particle physics, infinite-dimensional spinor geometry, generalized number theory, Planck constants, and the applications of TGD theory in research. The book is a valuable guide to TDG theory for researchers and advanced graduates in theoretical physics and cosmology.

Towards A Unified Soil Mechanics Theory demonstrates mathematical models for saturated and unsaturated soils by defining the effective stress equation. Chapters present hydraulic models that simulate water distribution in pores. Parameters from these models are then used to demonstrate the use of an effective stress equation to understand the mechanics of soils that have different material constitutions.

Key Features:

-Sequentially explains soil modeling techniques for easy understanding

-Demonstrates the use of an effective stress equation based on data from porous-solid models.

-Explains how porous-solid models can simulate the soilwater retention curves of materials.

-Establishes an elastoplastic framework for the volumetric behavior of unsaturated soils that is used to simulate the phenomenon of collapse upon wetting and the behavior of expansive soils. -Explains the practical application of fully a coupled hydro-mechanical (critical state) soil model

-Includes scientific references for further reading The third edition includes additional information on retention curves in deforming curves, the application of a coupled hydro-mechanical model simulating undrained tests and the behavior of soils during static compaction, and the use of a porous-solid model to develop a fully analytical equation for the relative hydraulic conductivity of soils. The new chapters also cover the experimental parameters used to derive the models. This edition also updates material from previous editions, and adds new scientific references.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics that has a wide range of applications. The book is a valuable reference to civil engineers, geotechnical engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.

With the application of the effective stress concept, the strength and volumetric behavior of saturated materials was clearly understood. For the case of unsaturated materials, a universally accepted effective stresses equation is still under debate. However, the use of the effective stress concept to develop constitutive models for unsaturated soils is becoming increasingly popular not only because the hydro-mechanical coupling observed in these materials is implicit in the formulation but also because simpler and more precise models can be established. Towards A Unified Soil Mechanics Theory demonstrates that the same strength and volume change equations used in saturated soil mechanics can be used for the case of unsaturated soils. In other words, the constitutive models developed for saturated soils can be used for unsaturated materials once the effective stress equation has been defined.

In this book, an analytical equation for the effective stress for unsaturated soils is established. This equation requires the knowledge of the superficial area of solids affected by the capillary phenomenon. In other words, we need to know how water distributes in the pores of the soil. This distribution can be modeled using a solid-porous model built on a regular network. However the size of the network required to correctly simulate the structure of a small soil sample cannot be managed with a common PC. For that reason, a probabilistic porous-solid model is developed. This model uses the pore size distribution in the form of a probabilistic function which in addition to the Laplace equation and the principle of continuity can be expressed as the probability of a pore of certain size to be filled or dry at suction during a wetting or drying path, respectively. In this way, the soil-water retention curves can be simulated and the effective stress at any suction during wetting or drying processes can be determined. Based on this approach, it is shown that unsaturated soils behave under the same principles for strength and volumetric behavior as saturated soils.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics. The volume will be a valuable reference to civil engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.

Pesticide control involves killing pest organisms or otherwise preventing them from destructive behavior. Pesticides are either natural or synthetic and are applied to target pests in a myriad of formulations (EC,WP, SP, FP, G etc.) and application technology systems (sprays, baits, slow-release diffusion, dust, etc.). In recent years, the bacterial genes coding for insecticidal proteins have been incorporated into various crops that dealt with the mortality of the pests feeding on them. Many other eco-friendly methods for insect pest control such as Integrated Pest Management (IPM), use of bio-pesticides etc., are becoming popular. Bio-pesticides and IPM should show good growth in the future, as there is growing concern for the eco-friendly organic agriculture and could be achieved through Good Agriculture Practices (GAP).

Use of pesticides requires a proper understanding of the chemistry, their handling and their use in crop protection or hygiene. These are toxic chemicals and require a good understanding of therapy and antidotes at the time of poisoning. This e-book covers pesticide chemistry, metabolic/degradation pathways, biochemical toxicology, therapy and antidotes, nano-pesticides and terminologies associated with pesticide toxicology. The book should serve as a text book for academia, or as a reference work for agriculturists, environmentalists and industry professionals.

This book serves as a treatise on lesser known ethnic varieties of cheese made in regions ranging from Mesopotamia to Europe and America. Cheese experts from different countries including Brazil, Croatia, Iran, Macedonia, Montenegro and Turkey bring together a rich blend of information about the traditional cheese in each region. The contributors describe the chemical and microbial characteristics, production technology and artisan culture of cheese making for each local variety.

The simple and systematic presentation of the information makes this a useful reference for a wide readership interested in food, dairy technology, and gastronomy, such as producers, consumers, academics and students. The book also represents an effort to bring forth knowledge about a culinary facet of the concrete cultural heritage of local communities which can benefit tourism and sustainability programs that involve the promotion of traditional dairy products.

[Series intro]

Current Developments in Food and Nutrition Research is a reference series intended for a multidisciplinary readership (researchers, students, and general readers) interested in subjects ranging from food science and technology to nutritional biochemistry and gastronomy.

Traditional Medicine in North East Africa: Research on Traditional Healer Preparations and Herbs explores the rich tapestry of traditional healing practices in North East Africa. This comprehensive work compiles the profound knowledge of indigenous herbalists and explores the intricate relationship between traditional healing and medicinal plants.

From combating diseases like cancer and diabetes to managing snakebites and obesity-related conditions, each chapter offers a detailed examination of plant-based remedies. Highlighting the contributions of plants like Moringa oleifera and Citrullus colocynthis, this book bridges the gap between ancient wisdom and modern research, making it essential for academics, researchers, and anyone interested in the healing powers of nature. Join us on this enlightening journey as we celebrate cultural diversity and uncover the enduring legacy of traditional medicine.

Key Features:

- In-depth studies on bioactive compounds and therapeutic properties of key African plants.

- Ethnobotanical insights into traditional healer practices.

- Comprehensive reviews linking traditional plant use to modern medical applications.