Bentham Science Publishers

Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes.

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

This E-book is a collection of articles that describe advances in speech recognition technology. Robustness in speech recognition refers to the need to maintain high speech recognition accuracy even when the quality of the input speech is degraded, or when the acoustical, articulate, or phonetic characteristics of speech in the training and testing environments differ. Obstacles to robust recognition include acoustical degradations produced by additive noise, the effects of linear filtering, nonlinearities in transduction or transmission, as well as impulsive interfering sources, and diminished accuracy caused by changes in articulation produced by the presence of high-intensity noise sources. Although progress over the past decade has been impressive, there are significant obstacles to overcome before speech recognition systems can reach their full potential. Automatic speech recognition (ASR) systems must be robust to all levels, so that they can handle background or channel noise, the occurrence on unfamiliar words, new accents, new users, or unanticipated inputs. They must exhibit more 'intelligence' and integrate speech with other modalities, deriving the user's intent by combining speech with facial expressions, eye movements, gestures, and other input features, and communicating back to the user through multimedia responses. Therefore, as speech recognition technology is transferred from the laboratory to the marketplace, robustness in recognition becomes increasingly significant. This E-book should be useful to computer engineers interested in recent developments in speech recognition technology.

The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of these diseases include malaria, dengue fever, leishmaniasis and Chagas disease. Therefore, an acute need for increasing the arsenal of drugs is required to fight against these neglected diseases for the guaranteed recovery and relief of many patients.

This eBook gathers important scientific research performed by scientists worldwide showing the state of the art of Medicinal Chemistry dedicated to the synthesis of compounds that are potentially bioactive against the causative agents of neglected diseases.

The contents of this eBook include chapters on recent advances in synthetic organic compounds for the prevention of Chagas disease, recent advances in the discovery of small organic molecules for the prevention and treatment of dengue fever, leishmaniasis, leprosy, therapeutic arsenal and drug discovery for lymphatic filariasis, therapeutic agents for the treatment of malaria, schistosomiasis and synthetic organic compounds as potential antitubercular drugs.

This eBook is intended for undergraduate and graduate students in institutes, colleges, universities and academies who want to specialize in the field of organic synthesis and medicinal chemistry. This eBook will also be a valuable resource of information for researchers in this field.

This book is a review of recent artificial intelligence approaches, initiatives and applications in engineering and science fields. It features contributions that highlight the use of techniques such as machine learning, mining engineering, modeling and simulation, and fuzzy logic methods in the fields of communication, networking and information engineering.

The collection of chapters should inspire scholars involved in theoretical and applied sciences to contribute to research using computational intelligence principles and methods in their respective research communities. Professionals working on systems engineering, communications, innovative computing systems and adaptive technologies for sustainable growth, will also be able to benefit from the information provided in the book.