Bentham Science Publishers

Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essence and diversity of genomics in contemporary science.

The third volume of this ebook series features a variety of articles exploring oncogenomics, mouse genetics, feline genetics, genetic mechanism for pain, the genetics of weeds and much more.

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.

Part II of the book set covers these topics:

- Anticancer targets for heterocyclic lead compounds

- Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity

- Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds

- Natural products as anticancer agents

Kidney transplantation is worldwide considered the best replacement therapy in patients with end-stage renal disease. However, although impressive improvements in surgical techniques and in the management of immunosuppression, long-term results have not significantly changed over the last decades.

The purpose of this book is not to be a comprehensive review on kidney transplantation, but it would overview the recent acquisitions in the field of kidney transplantation, by offering to clinicians the future directions and the possible fields of research to improve the long term outcome.

The book is divided into 27 chapters. The first part of the book is devoted to the basic principles of immunity and organ transplantation and the clinical evaluation of potential recipient. Moreover, in this section are discussed the most recent strategies to increase the donor pool trying to offer a kidney transplantation to a growing number of patients. The second part of the book is devoted to the immunosuppression. In these two chapters, the authors present an overview on the immunosuppressive management of kidney transplant recipients, with particular emphasis on the minimization of immunosuppression. The third part of the book is devoted to the complications of immunosuppression and to the psychological aspects of transplantation. This section is particularly detailed, and offers a complete point of view on the consequences and benefits of kidney transplantation. Last section is devoted to the future. The clinical tolerance and xenotransplantation are not still the present, but the authors illustrate the fields of application of these fundamental aspects of organ transplantation.

The authors and editors have tried to select an appropriate mix of citations, but it has not been possible to cite all the relevant articles. Apologies are due to those authors whose works we have failed to cite.

Our goal was to provide the most recent acquisitions in a practical manner. We hope that we have succeeded.

Special thanks to all the authors for their excellent and enthusiastic collaboration and special thanks to our patients to whom are dedicated all our efforts.

The phenomenon of resistance to motion through a fluid is believed to be a function of fluid-wall interaction. This theory is based on the assumption that under certain conditions a real fluid does not usually slip on the wall in contact with it and displays laminar flow. This set of conditions is known as a ‘no slip boundary condition’. But if a fluid is passed alongside a wall, the drag reduction in the laminar flow region can be calculated. In Laminar Drag Reduction, the frictional drag of an internal or an external fluid flow along a certain kind of hydrophobic wall is investigated. An analytic approach towards the mechanism of drag reduction is employed using Navier-Stokes existence and smoothness equations. The experimental results presented in this book show that frictional drag of a fluid alongside this hydrophobic wall decreases in comparison with fluid flow along a conventional wall or surface.

This form of laminar drag reduction represents a relatively new area of research, where the laminar flow can be controlled by microscopic surface modifications, allowing fluid flows to slip over a wall. Laminar Drag Reduction brings information about some interesting phenomena related to fluid slippage on a highly water-repellent surface. Readers, physics graduates and senior researchers alike, can benefit from the information presented in this book to tackle more challenging questions in fluid mechanics research.

This monograph is a collection of reviews that presents results obtained from new and somewhat unconventional methods used to fight multiple drug resistance (MDR) acquired by microorganisms and tumours. Two directions are considered: (i) the modification of non-antibiotic medicines by exposure to un-coherent, or laser optical radiation to obtain photoproducts that receive bactericidal or, possibly, tumouricidal properties and (ii) the development of new vectors (micrometric droplets of solutions containing medicinal agents) to transport medicines to targets based on optical and micro spectroscopic methods.

Chapters shed light on pendant droplets used for antibiotic drug delivery, the science of lasers and their interactions with fluids in pendant droplets and spectroscopic analyses of droplets used to treat MDR infections. It therefore equips researchers and medical professionals with information about tools that enable them to respond to medical emergencies in challenging environments.

The intended readership for this monograph includes graduate students, medical doctors, fluid physicists, biologists, photochemists, and experts in drug delivery methods employed in extreme conditions (such as those found in outer space and hypergravity conditions) who are learning about using techniques such as laser spectroscopy, biophotonics and optofluidics/microfluidics.

This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. The knowledge of physiological effects of LC-PUFAs at different levels is constantly expanding. Topics covered over 10 chapters thoroughly detail the role of omega-3 LCPUFAs in nutrition (gene regulation) and disease (clinical applications); information about food sources and recent intake recommendations is also explained. This book also discusses current data concerning the role of LC-PUFAs during pregnancy and lactation, in cognitive function, immune response, allergy, asthma, cardiovascular diseases, depression, obesity, and insulin resistance. The book should be useful for advanced graduate students, public health officials as well as researchers working with LC-PUFAs.

Publications on non profit management reflect three main trends. Some books describe the nonprofit experience in different countries focusing on how these experiences reflect the case of a particular organization in its specific cultural context. These case studies provide an interesting, but not representative, documentation of the issues to be discussed. On the opposite end, other books introduce theoretical approaches and conceptual models that investigate the emergence of the nonprofit phenomenon in a comparative way. Finally, some other books focus on developing the understanding and provide the guidelines on specific themes e.g. accountability, change, marketing etc. Learning Why and How, in contrast to the above, accounts for a comprehensive view of the organizational complexity of management in the nonprofit sector.

This e-book provides a systemic view of nonprofit organizations linking micro and macro level aspects of management. It combines sociological, organizational and psychological elements of organization studies and provides an in-depth understanding of various issues and dilemmas among readers, students and executives of nonprofit organizations and civil society.

This Ebook is designed for science and engineering students taking a course in numerical methods of differential equations. Most of the material in this Ebook has its origin based on lecture courses given to advanced and early postgraduate students. This Ebook covers linear difference equations, linear multistep methods, Runge Kutta methods and finite difference methods for elliptic, parabolic and hyperbolic equations. As a course in numerical analysis it contains a variety of finite difference schemes and efficient algorithms implemented in mathematics. The mathematical modulae attached to each chapter with solutions of practical examples should help readers to understand the text and apply the methods. It is expected that the readers will find theorems with proofs and applications interesting and informative.