Bentham Science Publishers

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. The book includes a critical reappraisal of lesions in conditions such as Alzheimer's disease. Common disorders such as cardiovascular disease appear to be prime inducing agents in neurodegenerative diseases. These observations should help researchers to reevaluate the investigative approach towards diseases of the central nervous system. The style follows the current text adopted by morphologists in terms that allow for further investigation by research workers. The text represents an attempt to generate a refreshing viewpoint of end stage CNS disorders that follow a long pre-clinical pathogenic course implicating common generically related and interacting etiologic agents. This book is meant to be a useful guide for researchers and clinicians interested in the development and treatment of CNS disorders.

Illustrated Pediatric Dentistry is intended to be a guide to undergraduate and postgraduate students in their understanding of pediatric dentistry.

This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives their broad perspective through the book content. This book is also the amalgamation of the thoughts of numerous subject experts of international repute.

Part 1 of this book features information about the developmental psychology of a child, dental caries, craniofacial growth and development, growth of the maxilla and mandible, dentition and occlusion, and oral mucosa.

Key Features:

- The 15, structured chapters keep the latest trends of the subject in mind

- The book content is illustrated with quality clinical images,

- Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders

- The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals

- The book includes modern and current state-of-the-art techniques used in the clinic

- Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

Illustrated Pediatric Dentistry is intended to be a guide to undergraduate and postgraduate students in their understanding of pediatric dentistry. This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives their broad perspective through the book content. This book is also the amalgamation of the thoughts of numerous subject experts of international repute. Part 3 covers several topics relevant to practical dentistry such as, pediatric crowns, prosthetic management, pental pulp, pediatric endodontics, (including regenerative medicine and instruments), traumatic dental injuries, sports dentistry, Systemic Fluorides, (like SDF) and pit and fissure sealants. Special topics like fental caries vaccine and post-COVID dental practice round up this book. Key Features: - The 18, structured chapters keep the latest trends of the subject in mind - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders - The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

This book is a compilation of innovative work on image processing applications for renewable energy systems. The chapters in the book describe the use of neural networks in multi-direction dynamic, topographical data frameworks which are designed to account for the distinctive contemporary issues faced when managing environmentally friendly power generation systems.

The topics covered include uncertainty analysis methods, computing technologies, automated control systems, performance analysis, riverfront analysis through image processing and solar power estimation methods, to name a few. The information is also complemented with a review of problems in the electric power sector in India.

This book is beneficial for professionals and researchers who work on hybrid techniques of GIS, remote sensing, image processing and the implementation of these techniques for utilizing renewable energy resources. Engineers who work on advanced algorithms for renewable energy applications will also get an updated perspective about relevant innovations in this industrial sector.

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field.

The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility.

In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break' leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion.

Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role.

This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.

Wind power capacity in the world has been increased by more than 30% over the last decade in countries which have prominent installations. Wind energy conversion systems (WECSs) based on the doubly-fed induction generator (DFIG) have dominated the wind power generation sector due to the outstanding advantages they provide, including small converter ratings (around 30% of the generator rating) and lower converter costs.

Due to the non-linearity of wind power systems, the DFIG power control setup presents a big challenge especially under conditions of high variance in wind-speed and parameter sensing. To overcome these major problems, an improved IDPC (Indirect Power Control) system based on PID (Proportional-Integral-Derivative) controller, has been proposed instead of the conventional power inverters.

This handbook covers information about IDPC based WECS. The book starts with a general introduction to wind power system basics. Subsequent chapters provide additional knowledge about robustness tests and adaptive / intelligent control systems employed in wind energy systems. The new concept of direct and quadrature current control (Ird & Irq) under MPPT (Maximum Power Point Tracking) strategy is also explained along with novel fuzzy logic type control systems. The authors have included detailed diagrams and an appendix of WECS parameters, making this handbook a useful primer for engineering students working towards completing licenses, Masters degrees and Post-graduation programs in advanced wind power energy systems.

Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinformatics and drug design in developing the latest advances of in silico approaches for lead discovery. It contains an overview of structure-based, ligand-based methods and current fragment-based methods as well as examples for successful applications of such methods in discovering new hit/lead molecules for important therapeutic targets. Treatment of receptor flexibility - which is one of the most important challenges for in silico screening today – has also been highlighted in the eBook. Biomedical scientists, biologists and chemists can find valuable information here that could help them to initiate or to complete chemical biology projects with the goal of designing new hit-to-lead molecules or chemical probes for chemogenomics projects.

This book is a comprehensive review of secondary metabolite production from plant tissue culture. The editors have compiled 12 meticulously organized chapters that provide the relevant theoretical and practical frameworks in this subject using empirical research findings. The goal of the book is to explain the rationale behind in vitro production of secondary metabolites from some important medicinal plants. Biotechnological strategies like metabolic engineering and the biosynthesis, transport and modulation of important secondary metabolites are explained along with research studies on specific plants. In addition to the benefits of secondary metabolites, the book also aims to highlight the commercial value of medicinal plants for pharmaceutical and healthcare ventures.

Topics covered in this part include:

1. In vitro propagation and tissue culture for several plants including Withania somnifera (L.) Dunal, Aloe vera, Oroxylum indicum (L) Kurz, Ocimum basilicum L, Rhubarb, Tea, and many others (including plants in Northern India).

2. Genetic Improvement of Pelargonium

3. Bioactive Components in Senna alata L. Roxb

4. Plant tissue culture techniques

The book caters to a wide readership. It primarily prepares graduate students, researchers, biotechnologists, giving them a grasp of the key methodologies in the secondary metabolite production. It is a secondary reference for support executives, industry professionals, and policymakers at corporate and government levels to understand the importance of plant tissue culture and maximizing its impact in the herbal industry.

This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives).

This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.

Degenerative nerve diseases are age-related, progressive and cause irreversible neurological loss that may lead to death. Chronic diseases like amyotrophic lateral sclerosis, Huntington's disease, Alzheimer's disease, and Parkinson's disease are associated with insoluble protein depositions and pose serious health challenges that may intensify in the coming decades. Current therapies only help to alleviate some of the physical or mental symptoms associated with neurodegenerative diseases, although there is currently no remedy for slow disease progression. In recent years, attempts have been made to discover a mechanism for neurodegenerative diseases and prospective treatment that may help mitigate aging effects and prevent these diseases. Natural products have been a constant source of new approaches for the treatment of neurodegenerative diseases, in particular plant alkaloids and polyphenolic compounds.

Indopathy for Neuroprotection: Recent Advances highlights herbal treatments that are preferred over conventional treatments in some regions. Book chapters focus on the effects of various medicinal plants that have shown promise in reversing pathological symptoms of neurodegenerative disease and highlight the neuroprotective role of medicinal herbal phytochemicals and their mechanism of action. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.