Bentham Science Publishers

Burns can cause life-threatening injury and the lengthy hospitalization and rehabilitations required in burn therapy lead to higher healthcare costs. The risk of infection has also been one of the important concerns of burn wound management. The purpose of the burn wound care management is speedy wound healing and epithelization to limit the infection. The topical application of therapeutic agents is quintessential for the longevity of patients having significant burns.

In recent times, research on herbal medicine for burn wound management has been vastly increased because of their safer toxicological profiles in contrast to synthetic medicines. Despite the promising therapeutic potential of herbal medicines in this area, herbal medications have some limitations which include low pharmacological activity, solubility and stability. Nanotechnology-based smart drug delivery approaches which involve the use of small molecules as nanocarriers, however, can help to overcome these biopharmaceutical challenges.

This book provides an overview of plant-mediated metallic nanoparticulate systems and nanophytomedicine based therapeutic treatment modalities for burn wound lesions. Nine chapters deliver updated information about nanomedicines for burn wound therapy. Contributions are written by experts in nanomedicine and phytomedicine and collectively cover the pathophysiology of wound lesions, current and future outlook of nanomedicine based treatments for burn wound lesions, the role of biocompatible nanomaterials in burn wound management, plant-mediated synthesis of metal nanoparticles for treating burn wound sepsis, phytomedicine based nanoformulations and the phyto-informatics models involved in the wound healing process which are used to select appropriate nanotherapeutic agents.

This reference serves as an accessible source of information on the topic of nanomedicine for burn treatments for all healthcare professionals (medical doctors, nurses, students trainees) and researchers in allied fields (pharmacology, phytomedicine) who are interested in this area of medicine.

This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine.

Key Features

- Explains the fundamentals of nanotechnology in drug discovery

- Includes up-to-date information on modern nanopharmaceutical manufacturing, nanomaterials, and nanoparticle-based drug therapy

- Practice questions for learners and a list of references for advanced readers for each chapter

Nanotechnology: A Quick Guide to Materials and Technologies invites readers to explore the cutting-edge world of nanotechnology, offering a comprehensive yet accessible introduction to this rapidly evolving field. The content provides a foundation for understanding the field and details the properties of significant nanomaterials. Readers will also gain insights into innovative processes while receiving a balanced perspective on the social and regulatory aspects of nanotechnology.

Key Features:

Foundational Knowledge: Begins with an overview of nanotechnology, its history, and its key concepts,

Diverse Nanomaterials: Explores various types of nanomaterials, including nanoparticles, nanowires, and carbon-based materials like graphene, detailing their properties and potential applications.

Advanced Applications: Explores the real-world uses of nanotechnology across multiple sectors, such as medicine, electronics, energy, and environmental science, demonstrating its transformative impact.

Fabrication and Characterization: Covers techniques for creating and analyzing nanomaterials, offering insights into the processes that drive innovation in the field.

Ethical and Societal Considerations: Discusses the broader implications of nanotechnology, including ethical, societal, and regulatory aspects

Ideal for students, educators, researchers, and industry professionals, this guide serves as an informative resource for anyone looking to deepen their understanding of nanotechnology.

Advances in technology have enabled medicinal chemists to discover and formulate several highly specific, biocompatible, and non-toxic therapeutic agents for clinical applications. Nanotechnology has achieved significant progress in the last few decades and is crucial in every field of science and technology. Nanotechnology-based pharmaceuticals offer multifaceted and alternative methodologies in comparison to the limitations of many conventional clinical therapies. Expertise in designing and developing nanoformulations has helped in targeted drug delivery. Recently, the use of innovative therapeutic agents, particularly in nanomedicine, has accounted for a significant portion of the global pharmaceutical market and is predicted to continue to grow rapidly in the near future. Nanotherapeutic Strategies and New Pharmaceuticals is an accessible multi-part reference which informs the reader about several new techniques based on nanotechnology. The chapters explain relevant topics in detail. The book is designed to encourage and help undergraduate, graduate and post-graduate students in the field of nanotherapeutics, pharmaceuticals and bio-organic chemistry through the use of didactic language and simple illustrations. Part 2 of this book covers the potential of nanotherapeutics and natural therapies for treating neurological diseases, targeting ion channels, signal transduction therapy, gene therapy of single gene mutation diseases and for nanoformulations for special purposes such as wound healing and stimuli-responsive drug delivery. The book also features a chapter that summarizes the types of nanoparticles tailored for specific molecular targets that mediate different diseases. The book set serves as a textbook for students in pharmacology and medical biochemistry, as well as a quick reference for researchers on bio-organic chemistry, as well as general readers interested in nanomedicine.

Plants have been widely used to treat diseases, owing to the presence of bioactive compounds (phytochemicals) which play important roles in health promotion and disease prevention. In recent years, advances in chemical extraction techniques, lifestyle and dietary choices for human health have increased the interest in the consumption and study of fruits, vegetables, and foods enriched with bioactive compounds and nutraceuticals. Thousands of dietary phytochemicals, such as flavonoids, phenolic acids, glucosinolates, terpenes and alkaloids, have been identified and categorized further according to a diverse array of biochemical properties. Many of these phytochemicals have been hypothesized to reduce the risk of several pathological conditions which include life threatening diseases such as heart disease and cancer, to name a few.

Natural Bioactive Compounds from Fruits and Vegetables as Health Promoters is a 2 book set which presents a summary of different classes of phytochemicals commonly found in common edible food sources. Each chapter details the general chemical structures of compounds, naturally present in specific fruits, vegetables and grains, their biological importance and mechanisms of action.

The book set is an essential handbook for anyone interested in the natural product chemistry of these common crops.

Part 1 of this set covers details about different fruits (banana, citrus fruits, pears, etc.). Part 2 covers legumes, nuts, seeds and cereals.

In nature lies the solution to restore teeth with minimal damage. In this groundbreaking book, the management of dental challenges is presented from a new perspective. Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems provides evidence-based solutions to dental challenges to researchers, practitioners and dental service providers. The main attribute of all these solutions is that they are all derived from natural ingredients. Natural ingredients are an effective alternative for dental care and management in contrast to synthetic products that have multiple side effects.

This book fills a knowledge gap on alternative and sustainable solutions derived from nature to respond effectively to dental challenges encountered in dental treatment for the conservation of the tooth. It is a compilation of the work of expert dentists that has been carried out in clinics for the management of dental problems.

Key Features

- Provides an insightful look at the prevention of dental diseases through evidence-based interventions using natural products in 9 referenced chapters

- Contains valuable contributions in restorative dentistry, such as caries prevention, enamel and dentin remineralization, dentin biomodification, dentin desensitization, vital pulp therapy, antioxidants, and tooth bleaching

- Provides an update on the current status of different ingredients used in oral health care products developed for commercial markets

- Includes notes on pathophysiology and diagnosis on specific conditions and sources of natural ingredients

The book is a valuable reference for trainees and professionals who want to enhance their restorative dentistry practice in the clinic.

Natural Immunomodulators: Promising Therapy for Disease Management discusses the use of natural immunomodulators as a promising therapy for managing various diseases. The book begins with an introduction to the immune system and the ways in which it can be modulated. This is followed by a discussion on the various diseases and disorders associated with the immune system, including autoimmune disorders, allergies, and immune deficiency conditions. The natural sources of immunomodulators, including plants, herbs, and other natural substances is also explained along with the importance of standardizing natural immunomodulator drugs, including the methods used to ensure their quality and consistency. The book also delves into the chemistry and analytical techniques used to study immunomodulators, clinical and pre-clinical bioassays. The next couple of chapters focus on the use of natural immunomodulators in cancer, the therapy of cancer and infectious diseases. Drug delivery and the strategy and regulatory perspective for natural immunomodulators. The final 2 chapters round up the contents with information about synthetic immunomodulators and the future perspective for the use of immunomodulators in disease management. Natural Immunomodulators: Promising Therapy for Disease Management is a comprehensive guide to the use of natural immunomodulators as a therapy for various diseases, and is a valuable resource for professionals and students interested in this topic. The book is aimed at health care professionals such as medical doctors, nurses, pharmacists, and life science and nutritionist professionals, as well as students.

Natural Products for Skin Diseases: A Treasure Trove for Dermatologic Therapy is an enlightening journey through the realm of natural remedies for various skin diseases. The editors have compiled information on effective and holistic treatment approaches that can be applied in clinical settings. This book brings diverse range of topics, including skin protection against harmful radiation, natural remedies for burns and wounds, management of skin pigmentation issues, and herbal treatments for scabies. It also explores the potential of natural cosmetics and their future applications, along with the use of natural products and nanoparticles in skin delivery. All chapters are contributed by experts in dermatology and herbal medicine, and are supplemented with scientific references for advanced readers. The book primarily serves as a textbook for students in medicine and dermatologists in training. It also serves as a valuable guide for dermatologists, researchers, and healthcare professionals, revealing the treasure trove of benefits that natural products offer for treating skin diseases.

Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with the local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF-α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive.

However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research-based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects.

Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology.

The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA, cytokines and anti-inflammatory mediators, and preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development.

The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policy makers.

Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives.

The second volume covers the following topics:

- A review of recent patents and natural products in clinical trials to treat schistosomiasis

- Natural products: the new intervention regimen for metabolic disorders

- Fluorine-containing drugs and drug candidates derived from natural products

- Natural products for the management of cardiovascular diseases

- Implication of natural compounds for the prevention of ocular diseases

A comprehensive and practice-oriented exploration of blockchain technology, tracing its evolution from Bitcoin to Ethereum and beyond. This volume explains blockchain's foundational principles, such as decentralization, immutability, and cryptographic security, before moving into real-world applications across finance, supply chain management, healthcare, governance, and emerging tech ecosystems.

With contributions from leading researchers and practitioners, the book examines both opportunities and challenges ranging from scalability and energy consumption to regulatory clarity and security. Readers also gain insights into cutting-edge developments like smart contracts, decentralized finance (DeFi), identity systems, Layer 2 solutions, DAOs, and blockchain's synergy with IoT and AI.

Key Features

Explains the core principles of blockchain, from decentralization to cryptographic security.

Traces the evolution from Bitcoin and Ethereum to DeFi, smart contracts, and dApps.

Demonstrates applications across finance, healthcare, supply chain, governance, and identity management.

Addresses pressing challenges, including scalability, energy use, regulatory frameworks, and security threats.

Explores future trends like interoperability, DAOs, Layer 2 solutions, and integration with IoT and AI.

Navigating through Technology in Modern Education explores the transformative impact of digital innovation in education. From introducing digital transformation to discussing the benefits and challenges, this book covers crucial topics like e-learning, artificial intelligence, big data, and the Internet of Things in education. With insights into factors for adopting technology and tailored learning experiences, this book equips readers with the knowledge to navigate the evolving landscape of modern education. Whether you're a seasoned educator or a newcomer, this book offers valuable insights into leveraging technology for enhanced learning experiences.

Agent technology has generated lots of excitement in the past decade. Currently, multi-agent systems (MAS) composed of autonomous agents representing individuals or organizations and capable of reaching mutually beneficial agreements through negotiation and argumentation are becoming increasingly important and pervasive.

Research on both automated negotiation and argumentation in MAS has a vigorous, exciting tradition. However, efforts to integrate both areas have received only selective attention in the academia and the practitioner literature. A symbiotic relationship could significantly strengthen each area's progress and trigger new R&D challenges and prospects toward the advancement of automated negotiators and argumentation tools.

Negotiation and Argumentation in Multi-Agent Systems presents the current state-of-the-art on the theory and practice of automated negotiation and argumentation in MAS. The eBook encourages the interaction between these two areas in data modelling and attempts to converge them toward mutual enhancement and synergism. Equally, the monograph brings together researchers and industry practitioners specialized in these areas to share R&D results and discuss existing and emerging theoretical and applied problems.

This book is intended as a textbook for graduate courses and a reference book for researchers, advanced-level students in Computers Science, and IT practitioners.

Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be quasi asymptomatic. This lack of overt symptomatology suggests that clinical laboratory tests are of the highest importance. Clinicians treating patients and clinical biologists operating in laboratories are often far apart from each other. They have a lot of things to share and to learn from each other. This e-book bridges the gap between these two groups of health professionals.

This book dives into the heart of how to design distributed control architectures for heterogeneous teams of humans, robots, and automated systems, enabling them to achieve greater cooperation and autonomy through the use of network technologies. It provides a wide range of practical, proven strategies for pervasive communication and collaborative problem solving abilities of humans, robots, and their environments. Each chapter consists of a presentation of findings from the latest research in networked robots and ambient intelligence. The chapters also detail how to allow robots to achieve universal access to the extended functionality of the environment that brings various cost effective services to those in need. Readers can envision a realistic view of what can be expected from a networked human robot cooperative environment in the next decade.

This monograph is a collection of selected articles on the subject of mood disorders such as depression and schizophrenia. It is divided into 3 sections: 1) Research methods in psychopharmacology - which highlights some established experimental techniques to study mood disorders in human and relevant animal models, 2) Pathophysiology of mood disorders – which explains the physiological and pharmacological mechanisms responsible for mood disorders and 3) New strategies for the treatment of mood disorders – a concluding section that provides recent examples on the beneficial effects of pharmacological and non-pharmacological interventions in the relief of mood disorders. The e-book serves as a primer for graduate students and researchers interested in the physiology and treatment of affective psychological disorders.

NBE is the official journal of the Institute of Complex Medical Engineering (ICME). The journal promotes the best interdisciplinary research in neuroscience and biomedical engineering. NBE welcomes contributions in any domain of neural and biomedical engineering ranging in content from practical/clinical applications through experimental science, technological developments to quantitative and/or statistical methodology discussions. NBE publishes the following article types: original articles, research reviews, and book reviews.

The goal of this journal is to establish a new forum for this interdisciplinary field so neuroscientists and biomedical engineers can publish their research works in one periodical. NBE is devoted to bridge the gap between Neuroscience and Biomedical Engineering , and to foster the mutual understanding in both fields.

Typical topics include, but certainly are not limited, to the following:
Neural Technology and Neural Rehabilitation
Neurology and Signal Processing
Biomedical Informatics
Biomechanics and Neural Control
Theoretical and Computational Neuroscience
Imaging Neuroscience

Key Features:

- Original research papers and special issues for topics
- Basic neurosciences, and biomedical engineering technologies
- Existing and potential clinical applications
- Periodic ‘Review Papers’ from world-recognized experts
- International scope
- No page charges
- Rapid publication times
- Free color in electronic version

Increasingly global and online social interactions and financial transactions involve digital data, computing devices and the internet. With cloud computing, remote computing, enterprise mobility and e-commerce on the rise, network security has become a priority. Selecting an appropriate algorithm and policy is a challenge for computer security engineers, as new technologies provide malicious users with opportunities to intrude into computer networks.

New Age Cyber Threat Mitigation for Cloud Computing Networks provides cloud and network engineers answers to cybersecurity challenges. It highlights new options, methodologies and feasible solutions that can be implemented in cloud architecture and IT Infrastructure, thereby securing end users. Chapters cover many topics related to cyber threats in the modern era.

These topics include:

Ransomware and DDoS attacks

Security algorithms

Design and implementation solutions for resilient and fault-tolerant cloud and network services

Security policy

End user data security The book is an essential resource for anyone involved in cloud computing and network security, including learners, professionals and enthusiasts.

New Avenues in Drug Discovery and Bioactive Natural Products is the second volume of the Natural Medicine book series. It is devoted to current research in drug discovery from natural sources. The volume features 13 chapters that cover modern analytical and scientific approaches. The book starts with chapters on advanced analytical and research techniques, such as genomic mining, quality control of herbal drugs, DNA fingerprinting, high-throughput screening, molecular docking and extraction techniques. The contributors provide a summary of challenges for researchers and commercial applications where possible. The book also features chapters dedicated to specific medicinal agents that target a disease (glycosides, SARS-CoV2 spike protein inhibitors, and andrographolides. The collection of important research topics in natural product chemistry aims to help the scholars and researchers in the scientific community that are involved in the extraction and development of new medicines.

This book is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. This book encompasses the multidisciplinary field of medicinal chemistry which overlaps the knowledge of chemistry, physics, biochemistry, biology and pharmacology.

New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances examines the molecular, pharmacological, and clinical dimensions of resistance development and highlights innovative therapeutic approaches aimed at overcoming multidrug-resistant organisms (MDROs), providing an in-depth exploration of emerging strategies to combat one of the most urgent public health challenges of our time—antimicrobial resistance (AMR).

Beginning with the mechanisms underlying bacterial resistance such as β-lactamase production, efflux pump activity, and membrane protein modification, the text underscores the growing threat posed by ESKAPE pathogens and CDC-classified priority infections. Chapters also explore cutting-edge interventions including bacteriophage therapy, discovery of novel antibacterial compounds from natural sources, and the use of nanoparticles and quorum-sensing inhibitors to suppress bacterial virulence.

Further sections discuss carbapenemase-mediated resistance, emphasizing enzyme classification, detection strategies, and the importance of clinical microbiology in guiding antibiotic stewardship. By integrating one-health perspectives that consider human, animal, and environmental dimensions, this book presents a holistic roadmap for addressing resistance evolution through innovation and responsible antibiotic use.

Key Features

Examines the molecular mechanisms driving antibiotic resistance in key bacterial species

Explores bacteriophage therapy as a promising alternative to conventional antimicrobials

Discovers natural-source compounds and novel drug leads for future antibiotic development

Analyses carbapenemase-mediated resistance and clinical detection techniques

Evaluates new therapeutic approaches including nanoparticle-based treatments and quorum-sensing inhibition

Promotes the one-health approach to tackling multidrug-resistant organisms globally

Congenital heart diseases are the most common neonatal malformations, ranging from 8 to 15/1000 live births in various communities. Improvement of knowledge in the genetic and etio-pathogenic aspects of these malformations as well as the technical advances of diagnostic and therapeutic tools have brought about a significant improvement in overall long-term patient outcome over the last few decades. This e-book is an update on the most recent genetic, diagnostic and therapeutic aspects of this pediatric cardiology. Specifically, the book explains, in detail, recent acquisitions in the field of interaction between the genome and heart development, advances in diagnostic non-invasive techniques and novel therapeutic applications of the percutaneous and "hybrid" cardiologic/surgical procedures. These developments in diagnostics and therapeutics will be extremely valuable for both pediatric and adult cardiologists treating patients with congenital heart defects.

The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.

Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.

This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.

Terraforming is the process of modifying a planet, moon, or other body to a more habitable atmosphere, temperature, or ecology. The idea of terraforming or colonizing other planets has recently become a topic of intense scientific interest and public debate. Geoengineering and terraforming, at their core, have the same goal: to enhance or revive the ability of a specific environment to support human life, society, and industry. New Worlds: Colonizing Planets, Moons and Beyond examines extra-terrestrial colonization plans with a critical eye. The ten chapters of the book provide a detailed review of the demographic and economic reasons behind this space imperative, technical and ecological solutions to improve the settlement of our own planet, enhancements of our current space industry. The book also covers interesting topics such as the terraformation of Mars, the moon, and other planets like Venus, colonizing the outer solar system (and beyond), and the ethical considerations in favor of space expansion. This simple, yet informative treatise is an essential read for anyone interested in the subject of space colonization