Bentham Science Publishers

Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms.

The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers.

The topics covered in this volume are:

- Peptides can play a major role in combating cancer diseases

- Studying of the CLL after treatment using fractal parameter of neoplastic lymphocytes detection (ΛNLD)

- Mechanistic insight of rhenium-based compounds as anti- cancer agents

- Targeting cancer-specific inflammatory components in cancer therapeutics

- Marine natural products as a source of novel anticancer agents: a treasure from the ocean

- PDX clinical trial design in anti-cancer research

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery.

The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase in cancer, recent updates in glioblastoma stem cells, latest approaches for cancer gene therapy and metabolic therapy for cancer were reviewed and updated. The role of pH regulation and application of hyperthermia, thiosemicarbazone derivatives, tamoxifen-based therapies for cancer treatment andproteome-based complex therapy of tumors, calcium signaling and angiogenesis, antineoplastic role of GHRH antagonists and therapeutic applications in human tumors and clinical oncology have been extensively discussed in the light of recent innovations.

The topics covered in this third volume will be valuable for those interested in scientists interests in methods for the prevention of cancer as well its management.

The fifth volume of this series entitled 'Topics in Anti-Cancer Research' presents an overview of recent developments in the field of cancer. The topics covered include regulatory policies, cell based anticancer drug delivery systems, anticancer agents targeting heat shock proteins, and tumor homing peptides (THPs) for treatment of cancer.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

The topics covered in the seventh volume of this series include:

- The role of inflammation in chemotherapy-induced neuromuscular effects

- Advances in nutrigenomics and relevant anti-cancer patents

- Stimuli-responsive nanocarriers for on-demand anti-cancer drug release

- Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer.

Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms.

The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers.

The topics covered in this volume are:

- Recent Patents on Exosome-Derived Therapeutic Agents

- Serrated Lesions of the Colon and Rectum: An Overview of Pathology and Emphasis on a New Classification

- Introducing the 188W/188Re and 144Ce/144Pr Plaques for Eye Cancers Brachytherapy

- ShcA Family of Adaptor Proteins: Dual Role in Cell Growth

- Hormones Management as Anticancer Treatment and Protection: Functions and Mechanism of Action

Tourism and Hospitality Management – A Modern Fusion of Sectors assess the evolving landscape of global tourism, highlighting how tradition and innovation intersect to shape new forms of travel and hospitality. Through interdisciplinary perspectives, this collection explores emerging trends such as digital detox tourism, virtual reality in guest experiences, robotic technologies in kitchens, and the growth of e-tourism across regions like India, Sri Lanka, Bangladesh, and Turkey.

The book investigates both the technological and cultural transformations driving the sector, while also addressing post-pandemic shifts in traveler behavior, sustainability concerns, and the importance of community-based tourism models. Strategic frameworks like the e-Tourism Value Chain Model (e-TVCM) are presented to help bridge theory and practice.

Key features:

Integrates perspectives from sociology, tech, marketing, and cultural studies

Highlights sustainable, mindful, and community-based travel models

Analyzes “next-normal” tourism behaviors and ethical concerns

Presents strategic tools and models for industry application

Towards A Unified Soil Mechanics Theory demonstrates mathematical models for saturated and unsaturated soils by defining the effective stress equation. Chapters present hydraulic models that simulate water distribution in pores. Parameters from these models are then used to demonstrate the use of an effective stress equation to understand the mechanics of soils that have different material constitutions.

Key Features:

-Sequentially explains soil modeling techniques for easy understanding

-Demonstrates the use of an effective stress equation based on data from porous-solid models.

-Explains how porous-solid models can simulate the soilwater retention curves of materials.

-Establishes an elastoplastic framework for the volumetric behavior of unsaturated soils that is used to simulate the phenomenon of collapse upon wetting and the behavior of expansive soils. -Explains the practical application of fully a coupled hydro-mechanical (critical state) soil model

-Includes scientific references for further reading The third edition includes additional information on retention curves in deforming curves, the application of a coupled hydro-mechanical model simulating undrained tests and the behavior of soils during static compaction, and the use of a porous-solid model to develop a fully analytical equation for the relative hydraulic conductivity of soils. The new chapters also cover the experimental parameters used to derive the models. This edition also updates material from previous editions, and adds new scientific references.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics that has a wide range of applications. The book is a valuable reference to civil engineers, geotechnical engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.

With the application of the effective stress concept, the strength and volumetric behavior of saturated materials was clearly understood. For the case of unsaturated materials, a universally accepted effective stresses equation is still under debate. However, the use of the effective stress concept to develop constitutive models for unsaturated soils is becoming increasingly popular not only because the hydro-mechanical coupling observed in these materials is implicit in the formulation but also because simpler and more precise models can be established. Towards A Unified Soil Mechanics Theory demonstrates that the same strength and volume change equations used in saturated soil mechanics can be used for the case of unsaturated soils. In other words, the constitutive models developed for saturated soils can be used for unsaturated materials once the effective stress equation has been defined.

In this book, an analytical equation for the effective stress for unsaturated soils is established. This equation requires the knowledge of the superficial area of solids affected by the capillary phenomenon. In other words, we need to know how water distributes in the pores of the soil. This distribution can be modeled using a solid-porous model built on a regular network. However, the size of the network required to correctly simulate the structure of a small soil sample cannot be managed with a common PC. For that reason, a probabilistic porous-solid model is developed. This model uses the pore size distribution in the form of a probabilistic function which in addition to the Laplace equation and the principle of continuity can be expressed as the probability of a pore of certain size to be filled or dry at suction during a wetting or drying path, respectively. In this way, the soil-water retention curves can be simulated and the effective stress at any suction during wetting or drying processes can be determined. Based on this approach, it is shown that unsaturated soils behave under the same principles for strength and volumetric behavior as saturated soils.

This revised edition brings additional information about an elastoplastic framework for expansive soils, hydro-mechanical coupling and a fully coupled model. The additional chapters also cover the experimental parameters used to derive the models. An updated set of references and a list of abbreviations is also included in this edition.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics. The volume will be a valuable reference to civil engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.

Toxic Effects of Nanomaterials provides an authoritative work of international experts in the field of nanotoxicology spanning 8 chapters. A key feature of the e-book is a broad coverage of phytotoxicity of nanoparticles, which is largely neglected in many texts. The first couple of chapters of this book deal with the toxicity of nanoparticles in plants. This is followed by a discussion on the toxicities of iron oxide, titanium oxide and silicon oxide nanoparticles. Next, the volume provides a comprehensive review of methodologies used in nanotoxicology surveys. The concluding chapters highlight the risks associated with the use of nanoparticles and the environmental impact of nanomaterials. Such a broad coverage of nanotoxicology renders this book highly beneficial to the scientists from multidisciplinary areas including nanotechnologists, toxicologists, pharmacologists, environmental chemists and biomedical scientists. This book would equally be useful for the individuals advocating for sustainable use of nanotechnology.

Pseudomonas aeruginosa is known as a persistent bacterial pathogen. Antibiotics are currently the most common bacterial treatment for related infections but cases of microbial resistance are on the rise. Toxin-Antitoxin Systems in Pseudomonas aeruginosa describes one of the most important antimicrobial targets in the bacterium species. The contributors have compiled comprehensive information on the subject. The reference initially acquaints the reader with key topics about P. aeruginosa infection including virulence factors, pathogenicity, epidemiology, laboratory diagnosis and antibiotic resistance. This is followed by detailed chapters on toxin-antitoxin systems which explain their role in the bacterial pathogenesis with reference to P. aeruginosa.

The comprehensive information on the subject makes this an ideal reference for newcomers to the field of bacteriology and target discovery. Students of medical microbiology and medical professionals who are interested in the finer details of P. aeruginosa pathogenicity will also be equipped with sufficient information to join the discussion on this topic with fellow researchers.