Bentham Science Publishers

Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs), which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for drugs. Nano-drug delivery has emerged as a promising technology that results in early detection and better treatment of various cancers. The approved nanoparticles currently used in cancer treatment strategies include liposomes, dendrimers, polyplexes, solid lipid nano-carriers, etc. These nanocarriers shall provide a quick, safe, and cost-effective method in cancer therapy and management. This book contains thirteen chapters focusing on the treatment of various cancers, i.e., lung, breast, cervical, ovarian, colon, prostate, head and neck, etc., through nanocarrier drugs. The chapters include reviews on a wide variety of advanced data from existing and ongoing clinical research and major regulatory considerations.

The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of complementary and alternative medicine for in the treatment of diabetes, cancer, neurodegenerative disorders, microbial infections, etc., The 15 chapters are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plat sources.

Therapeutic Uses of Plant Secondary Metabolites is timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.

This comprehensive book explores the techniques, materials, and real-world applications of thermal spray coatings across various industries, including power generation, aerospace, medical, and automotive sectors.

Readers will learn about the basic science and engineering aspects of thermal spray technology, its historical developments, and the diverse range of materials used, from metallic to ceramic materials, and nano-crystallization materials. Distinct thermal spray techniques are explained (flame spray, detonation-gun spray, high-velocity oxy-fuel spray, electric arc spray, plasma spray and cold spray). Chapters on advanced topics also give an understanding of crucial material properties such as high temperature corrosion, oxidation, erosion or wear resistance, and biocompatibility.

Key features

- Contributions from materials science experts with references for each topic

- Gives a comprehensive overview of materials and distinct spray techniques used in thermal coatings

- Dedicated chapters for applications of thermal coatings in different industries

- Covers recent trends and new advances such as surface modification techniques to improve functionality and performance

This book is intended as a resource for an in-depth understanding of the fundamentals and applications of thermal spray coatings for students, professionals and researchers in materials science and chemical engineering disciplines.

Thin-Film Transistor Reliability provides a comprehensive analysis of the reliability challenges in thin-film transistors (TFTs), essential components in modern electronics. Covering topics from fundamental structures to degradation mechanisms, this book equips researchers and engineers with the tools to assess, analyze, and improve TFT reliability.

The book systematically explores key reliability concerns, including performance characterization, defect states, voltage stress effects, circuit-level degradation, and environmental influences. Advanced reliability analysis methods and practical improvement strategies are also discussed, offering insights into future developments.

Key Features:

- In-depth discussion of TFT degradation mechanisms and reliability concerns.

- Comprehensive analysis techniques, including transfer curve and noise analysis.

- Effects of DC/AC voltage stress, self-heating, and environmental factors.

- Strategies for enhancing TFT reliability through structural modifications.

Thriving Across the Lifespan and Around the Globe: Day in the Life Visual Research Approach is the result of several decades of international, pan-disciplinary research-team collaborations using quasi-ecological visual methodologies to investigate the psychosocial development of children in diverse communities. The initial studies highlighted in this work involved filming a ‘Day in the Life’ of toddlers and primary school children, their families, and schools in diverse communities in Asia, South and North America, and Europe. Filmed in their homes and communities for an entire day, the youngest participants were commonly seen to be thriving in diverse psychosocial domains, such as in their security strivings, emergent literacy and graphic representations, and musicality. Research shows that the nature of a child's development can vary in as many ways as there are diverse contexts. Thriving in the transition from home to primary school is a second developmental milestone investigated in the research.

The book serves as an account of the lived experiences of thriving children,among their families, their schools and their communities. The contents give an invaluable insight into the psychology of early childhood while giving the reader an opportunity to understand the resilience of mobile early teenagers as well as independent older adults. The contributions in the book also provide an additional layer to our understanding of visual ethnography by covering such phenomena as agency and communitarianism, spirituality, and the place of humour in the context of challenges encountered across the lifespan. Through presenting quasi-ecological experimental approaches, this reference enhances the reader’s insight into the texture and nature of thriving in situ, in natural contexts.

Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it often complicates medical situations as a coexisting disorder. In this handbook, the contributors have compiled comprehensive information on the subject to provide the reader a comprehensive review of current medical literature and guidelines for cancer-associated thrombosis.

Key Features

-clinically oriented text for application in healthcare settings

-current, evidence-based literature reviews and references

-includes guidelines on VTE prophylaxis, heparin effects and more

-includes information about special cases

Thrombosis in Cancer: A Medical Professional's Guide to Cancer Associated Thrombosis is an informative handbook for a broad range of readers in medicine, including generalists, residents, and graduate-level trainees.

Thyroid hormones are involved in numerous physiological processes as regulators of metabolism, bone remodeling, cardiac function and mental status. Moreover, thyroid hormones are of special importance in fetal development, more particularly, in the development of the brain. Thus, maintenance of normal thyroid functioning is essential for psychological, biochemical, immunological, endocrinal and physiological well being of the body as well as normal growth and development. Understanding how the thyroid gland is affected by adverse factors can help clinicians to handle emergency situations or apply preventive care measures to patients. Thyroid Toxicity is a comprehensive monograph on thyroid toxicology. It gathers all information about the toxic effects of different kinds of factors (hormonal, radiation and chemical) that affect the thyroid system. The ebook gives a brief introduction to the thyroid system and answers several important questions about the topic such as the biochemical mechanisms through which various compounds (for example, pesticides, food additives, etc.) induce toxicity on the thyroid gland, how endocrine disruption alters the physiology of the human body and brain as well as how radiation harms the thyroid gland. Thyroid Toxicity is the definitive reference for any medical officer, endocrinologist, or toxicologist seeking knowledge on thyroid gland toxicology.

This comprehensive textbook offers an in-depth exploration of how thyroid hormones influence brain development and function, particularly on cellular and molecular mechanisms. Readers will find current insights into the complex interplay between the thyroid and neurological systems, making it a valuable resource for researchers, advanced learners and clinicians in the fields of endocrinology, neuroscience, and developmental biology.

The book starts with a review of thyroid physiology, setting the stage for subsequent chapters that cover specific topics such as the impact of maternal thyroid hormones on fetal brain development and the effects of iodine deficiency. From here, the book progresses to cover the regulation of brain gene expression, neuronal and glial cell differentiation, and myelination by thyroid hormones, and how thyroid hormones shape the brain. Finally, the book addresses the link between thyroid dysfunction and mood disorders.

Key features

- A thorough examination of the historical and the latest research findings through 14 chapters

- Clear explanations of molecular pathways

- Emphasis on both theoretical knowledge and practical applications

- Detailed and research-focused content scientific references for further reading

he immune system is highly complex, it senses foreign invaders, thus protecting the body. The adaptive arm of the immune system confers long-term protection, whereas the innate immune system confers immediate protection. The immune system uses pattern recognition receptors that are able to sense the molecular patterns associated with pathogens. Toll-like receptors (TLRs) are important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity. This book covers the role of TLRs in several vector-borne Diseases. Starting with an introduction to these diseases, the book explains the different types of receptors involved in these diseases. The diseases are then covered in separate chapters, including: malaria, lymphatic filariasis, visceral leishmaniasis, dengue fever, chikungunya, West Nile fever, and Japanese encephalitis. The book is a handy reference for researchers and trainees involved in clinical medicine and infection control. It can also serve as supplementary reading material for Students undertaking courses in biotechnology, public health, entomology, immunology, epidemiology, and life sciences.