RESULTS:

Background: The hand is an excellent work tool that provides the functional ability to mechanical work. The hand is affected in rheumatoid arthritis (RA) patients it is a significant problem in the functional sphere as a result of deformities the grasping function limitation and muscle strength. Objectives: The aim of the study was the assessment of grip strength endurance and manipulation abilities of rheumatoid hands with or without deformities treated with methotrexate (MTX) or MTX plus biologics (MTX+BIO). Methods: The study involved 80 RA women (40 received MTX+BIO 40 MTX) treated at the Rheumatology Department of the Central Clinical Hospital of Interior Affairs in Warsaw. VASpain DAS28 SDAI HAQ HAQ hands estimation of hand grip strength endurance and manipulation ability were analyzed. Results: In group MTX+BIO values of DAS28 (3.7±1.3 vs. 4.3±1.2 p=0.019) HAQ (0.72 ± 0.57 vs. 1.08± 0.87 p=0.011) and HAQ-hand (0.85±0.65 vs. 1.19±0.68 p=0.024) were statistically lower than in MTX group. Hand deformations were recorded in 35 (43.7%) cases 16 (40%) in MTX group 19 (47.5%) in MTX+BIO. Comparison of grip strength endurance and manipulation ability showed better results in MTX+BIO group with deformities (significance level from 0.013 to 0.046) than in MTX group. Relative differences in hand function in MTX + BIO group ranged from 10.8% (maximal power grip strength) to 127.6% (minimal hand endurance) after disease duration adjustment - from 28.2% (maximal power grip strength) to 148.4% (minimal hand endurance). Conclusion: Measuring grip strength hand endurance manipulation abilities are useful in RA patients with hand deformities.