RESULTS:
1 - 3 of 3 for ""Mucosal injury""
Prevention and Treatment of Regimen-Related Mucosal Toxicity
Current standard treatments for cancer are associated with major dose-limiting toxic effects on healthy tissue. The mucosal layers of the body are particularly sensitive to regimen-induced damage with patients suffering many unpleasant and potentially life-threatening side-effects. In recent years there has been an increase in the understanding of the pathobiology of regimen-related mucosal injury which has lead to a number of exciting inventions for its prevention and treatment being recently patented. Agents such as growth factors cytokines receptor agonists/antagonists and antiinflammatory agents are among those in development in this emerging field. The complexity of mucosal injury poses a challenge for researchers however rational targeting of intervention strategies to critical mechanisms will lead to further progress.
A Review on Gastroprotective Mechanisms and their Augmentation by External Agents
The oral route is the most typical way to provide medication due to its benefits including non-invasiveness patient compliance and ease of medication delivery. One of the most often recommended pharmacological groups for the treatment of pain and inflammatory disease is non-steroidal anti-inflammatory medicines. However the major side effect of non-steroidal anti-inflammatory medicines is PUD (peptic ulcer disease). An imbalance in the action of gastroprotective and aggressive agents causes gastric ulcers. Gastroprotective mechanisms include the mucus layer mucosal repair capacity gastric epithelium and gastric blood flow. The purpose of this review is to provide an update on gastroprotective mechanisms. As discussed mucin acts as a filter and gastric epithelial defenses include the cell barrier stem cells and a sensor on the mucosal surface.
Prevention and Treatment of Regimen-Related Mucosal Toxicity
Current standard treatments for cancer are associated with major doselimiting toxic effects on healthy tissue. The mucosal layers of the body are particularly sensitive to regimen-induced damage with patients suffering many unpleasant and potentially life-threatening side-effects. In recent years there has been an increase in the understanding of the pathobiology of regimen-related mucosal injury which has lead to a number of exciting inventions for its prevention and treatment being recently patented. Agents such as growth factors cytokines receptor agonists/antagonists and anti-inflammatory agents are among those in development in this emerging field. The complexity of mucosal injury poses a challenge for researchers however rational targeting of intervention strategies to critical mechanisms will lead to further progress.