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1 - 2 of 2 for ""Garcinia cambogia""
Nutrigenomic Analysis of Diet-Gene Interactions on Functional Supplements for Weight Management
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic. According to the World Health Organization more than 60% of the global disease burden will be attributed to chronic disorders associated with obesity by 2020. Meanwhile in the US the prevalence of obesity has doubled in adults and tripled in children during the past three decades. In this regard a number of natural dietary supplements and micronutrients have been studied for their potential in weight management. Among these supplements (-)-hydroxycitric acid (HCA) a natural extract isolated from the dried fruit rind of Garcinia cambogia and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss. Utilizing cDNA microarrays we demonstrated for the first time that HCA-supplementation altered the expression of genes involved in lipolytic and adipogenic pathways in adipocytes from obese women and up-regulated the expression of serotonin receptor gene in the abdominal fat of rats. Similarly we showed that NBC-supplementation up-regulated the expression of myogenic genes while suppressed the expression of genes that are highly expressed in brown adipose tissue in diabetic obese mice. The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-theart nutrigenomic technologies will be systematically discussed in this review.
A Critical Scientific Review on Withania somnifera, Garcinia cambogia and Curcumin Supplements: Food Forensics Perspective
Abstract: Food forensics is an emerging branch that applies scientific knowledge for the verification and authentication of food supplements. The term “dietary supplement” refers to a diverse set of preparations that are deemed to be essential for the well-being of the human body. These supplements consist of various physiologically active substances that produce effects on the body. However a major issue with these supplements is that they are neither considered as medicines nor as a food products. Due to this such food supplements are prone to adulteration and counterfeiting. In this review three widely used supplements namely Curcuma longa Withania somnifera and Garcinia cambogia supplements are considered. Chemistry pharmacology and benefits of three are being discussed along with the analytical techniques for their analysis. Chromatographic techniques are popular for the examination of dietary supplements. Several such analytical techniques are being used to detect and identify the physiologically active constituents as well as adulterants in dietary products. This review intends to demonstrate the overall issues regarding dietary supplements.