RESULTS:
1 - 2 of 2 for ""β-amyloid peptide (Aβ)""
Carbon-11 Labeled Tracers for In Vivo Imaging of P-Glycoprotein Function: Kinetics, Advantages and Disadvantages
P-glycoprotein (P-gp) is a drug efflux transporter with broad substrate specificity localized in the blood-brain barrier and in several peripheral organs. In order to understand the role of P-gp in physiological and patho-physiological conditions several carbon-11 labelled P-gp tracers have been developed and validated. This review provides an overview of the spectrum of radiopharmaceuticals that is available for this purpose. A short overview of the physiology of the blood-brain barrier in health and disease is also provided. Tracer kinetic modelling for quantitative analysis of P-gp function and expression is highlighted and the advantages and disadvantages of the various tracers are discussed.
Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.
Phytochemical investigation of the methanolic extract of Eryngium campestre L. aerial parts led to isolation of eleven known flavonol glycosides. Structures were elucidated by spectroscopic and chemical methods. The methanol extract of E. campestre and the isolated flavonols exhibited moderate to strong antioxidant activity in DPPH radical scavenging and reducing power assays. Eryngium campestre extract showed significant inhibition of the A.A.β-amyloid Aβ 42 (IC50 = 155.75±7.43 ng/ml) without significant reduction in total Aβ (Aβ 40 + Aβ 42) levels in human H4 cell line using sensitive sandwich enzyme linked immunosorbent assay (ELISA). The results showed no inhibition activity of the extract against COX-1 and COX-2 up to 400 ng/ml concentration.