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2000
Volume 1, Issue 1
  • ISSN: 2210-2965
  • E-ISSN: 2210-2973

Abstract

Neural repair and regeneration for tissue engineering is the most promising strategy for treating human brain neurological diseases. Main bottle neck of the clinical therapy is that no ideal scaffold biomaterials as vehicle of neural stem cells (NSCs) and growth factors have been developed yet, even for the clinical tests. To solve this problem, a lot of work has been done and numerous kinds of biomaterials have been studied. The interaction between NSCs and biomaterials, especially the regulation of NSCs by materials, plays an essential role during the scaffold biomaterial selection. The article gives an overview on the recent progresses on regulation of NSCs by biomaterial and shows some recent patents regarding the progress in the field.

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/content/journals/rpgm/10.2174/2210296511101010019
2011-01-01
2025-10-13
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/content/journals/rpgm/10.2174/2210296511101010019
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  • Article Type:
    Research Article
Keyword(s): (SHH-GLI) pathway; 3-D matrix adhesion; Alzheimer's disease; azacytidine (5AzaC); basic fibroblast growth factor (bFGF); bioactive factors; biocompatible; biodegradable; biodegradable poly-hydroxyacetic acid; biomimetic matrix; cell adhesion; central nervous systems; cerebral ischemia; Chitosan; Chitosan films (Chi-F); chitosan multimicrotubule conduits (Chi-MC); chitosan porous scaffolds (Chi-PS); chondrogenic cell; CNTF (ciliary neurotrophic factor)-collagen gel-controlled delivery system; Collagen Scaffolds; comprising leukemia inhibitory factor; conducting; cytokines; demyelinating disease; dopaminergic neurons; electrospinning; embryonic stem cell; ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and; Extracellular Matrix (ECM); fibrin; fibronectin; Gelatin; gene expressions; glial cell adhesion; growth factor-reduced Matrigel (gfrMG); Huntington disease; Hyaluronic Acid (HA) Hydrogel; immunologically inert; infection-resistant; inflammation-resistance; laminin; methacrylamide chitosan (MAC); mood disorders, manic depressive disorders; N-hydroxysuccinimide (NHS); nanofabrication; nanolithography technique; Natural biomaterials; neural repair; neural stem cells (NSCs); neurodegenerative disorders; neurotrophin-3 (NT-3); nylon; oligodendrocytes; photoencapsulated; poly (beta-(1, 4)-2-amino-2-deoxy-D-glucose; poly (beta-(1, 4)-D-glucosamine; Poly (DLlactide-co-glycolide acid; poly (ethylene) glycol (PEG); poly-lactic acid; polyhydroxyalkanoates (PHA) matrix; polyurethane; polyurethane (PU); proliferation; regenerative medicine; scaffold biomaterial; Seeding human embryonic stem cell-derived NPC (hESC-NPC); Self-assembling peptide; Self-assembling peptide nanofiber scaffold (SAPNS); signal pathway; silica gel; sonic hedgehog-GLI; spinal cord injury (SCI); synapses; synthetic biomaterials; Tissue engineering; traumatic brain injury; tyrosine hydroxylase (TH); valproic acid (VPA); Young's elastic modulus (E-Y)
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