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2000
Volume 11, Issue 2
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Calcitonin (CT) is a peptide hormone produced by the parafollicular cells of the thyroid gland in mammals and by the ultimobranchial gland of birds and fish. Salmon calcitonin (sCT), which is more potent and longer lasting than human CT, has been used widely for the treatment of osteoporosis, paget's disease, hypercalcemic shock and chronic pain in terminal cancer patients. sCT is one of the many bioactive peptides that require C-terminal amidation for full biological activity. In this study we describe the overexpression and over-production of C-terminal amidated sCT in recombinant Streptomyces avermitilis. With this approach the utilization of expensive peptide synthesis can be circumvented.

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/content/journals/ppl/10.2174/0929866043478266
2004-04-01
2025-10-13
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/content/journals/ppl/10.2174/0929866043478266
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  • Article Type:
    Review Article
Keyword(s): amidating enzyme; plasmid ChiC9; salmon calcitonin; Streptomyces avermitilis
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