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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Volumetric Behavior of the Molten Globule State of Canine Milk Lysozyme
- Source: Protein and Peptide Letters, Volume 11, Issue 4, Aug 2004, p. 325 - 330
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- 01 Aug 2004
Abstract
The effect of pressure on the unfolding of the molten globule (MG) state of canine milk lysozyme (CML) was examined using ultraviolet spectroscopy. The volume changes of the MG-unfolded-state transition were observed at pH 2.0 and around 20 to 60°C, but no volume change has been found for bovine α-lactalbumin, which is homologous to CML. Our results suggest that the MG state of CML possesses a tightly packed hydrophobic core.
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