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2000
Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Peptic ulcers have a significant impact on global mortality and morbidity rates. The primary causative factors explored in this review include infection, unhealthy lifestyle choices, and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Addressing this pressing health issue requires raising awareness and developing novel medications and therapies, which necessitates further research. This article encompasses a wide range of information on peptic ulcers, covering their epidemiology, etiological factors, pathogenesis, antiulcer agents, synthetic compounds, and experimental animal models. It serves as a valuable resource for researchers, healthcare professionals, and policymakers by providing a comprehensive overview of peptic ulcer disease. The review emphasizes the critical role of experimental animal models in advancing our understanding of the disease and facilitating the development of novel treatments. By utilizing these models, researchers can gain deeper insights into the pathogenesis of peptic ulcers and evaluate potential therapeutic interventions. Furthermore, this review highlights the need for continued research efforts to address the challenges posed by peptic ulcer disease. By fostering awareness, promoting research, and encouraging the implementation of effective therapies, we can collectively strive towards reducing the burden of peptic ulcer disease and improving the health and well-being of individuals worldwide.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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References

  1. ProctorMJ DeansC Complications of peptic ulcers.Surgery2014321159960710.1016/j.mpsur.2014.09.005
     [Google Scholar]
  2. CoelhoJ.C. Digestive System: Clinic and Surgery1182
     [Google Scholar]
  3. HeH. LiX. YuH. ZhuS. HeY. KomatsuK. GuoD. LiX. WangJ. LuoH. XuD. ZouK. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway.J. Nat. Med.201973233935210.1007/s11418‑018‑1256‑030523551
     [Google Scholar]
  4. ZhangQ. HuangN. WangJ. LuoH. HeH. DingM. DengW.Q. ZouK. The H+/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells.Fitoterapia2013898921021710.1016/j.fitote.2013.05.02123742858
     [Google Scholar]
  5. ShinJ.M. VaginO. MunsonK. KiddM. ModlinI.M. SachsG. Molecular mechanisms in therapy of acid-related diseases.Cell. Mol. Life Sci.200865226428110.1007/s00018‑007‑7249‑x17928953
     [Google Scholar]
  6. LanasA ChanFK Peptic ulcer disease.Lancet20173901009461362410.1016/S0140‑6736(16)32404‑7
     [Google Scholar]
  7. SalariN. DarvishiN. ShohaimiS. BartinaY. AhmadipanahM. SalariH.R. MohammadiM. The global prevalence of peptic ulcer in the world: a systematic review and meta-analysis.Indian J. Surg.2021219
     [Google Scholar]
  8. ZulloA. HassanC. CampoS.M.A. MoriniS. Bleeding peptic ulcer in the elderly: risk factors and prevention strategies.Drugs Aging2007241081582810.2165/00002512‑200724100‑0000317896831
     [Google Scholar]
  9. HuangC.Y. LaiW.Y. SunM.F. LinC.C. ChenB.C. LinH.J. ChangC.M. YangC.H. HuangK.C. YenH.R. Prescription patterns of Traditional Chinese Medicine for peptic ulcer disease in Taiwan: A nationwide population-based study.J. Ethnopharmacol.201517617631132010.1016/j.jep.2015.11.00226549268
     [Google Scholar]
  10. SayehmiriK AbangahG KalvandiG TavanH AazamiS Systematic review and meta-analysis methods prevalence of peptic ulcer in Iran.Govaresh.201620250258
     [Google Scholar]
  11. SayehmiriK AbangahG KalvandiG TavanH AazamiS Prevalence of peptic ulcer in Iran: Systematic review and meta-analysis methods.J Res Med Sci.2018238
     [Google Scholar]
  12. Badi AlbaqawiA.S. Abo el-FetohN.M. Abdullah AlanaziR.F. Farhan AlanaziN.S. Emad AlrayyaS. Nughaymish Mulfi AlanaziA. Trad AleneziS.Z. Alrkowi AlanaziR.A. Muaddi AlshalanA. Tabaan AleneziO. Bakr AliW.M. Profile of peptic ulcer disease and its risk factors in Arar, Northern Saudi Arabia.Electron. Physician20179115740574510.19082/574029403613
     [Google Scholar]
  13. WuH.C. TuoB.G. WuW.M. GaoY. XuQ.Q. ZhaoK. Prevalence of peptic ulcer in dyspeptic patients and the influence of age, sex, and Helicobacter pylori infection.Dig. Dis. Sci.200853102650265610.1007/s10620‑007‑0177‑718270835
     [Google Scholar]
  14. SungJ.J.Y. KuipersE.J. El-SeragH.B. Systematic review: the global incidence and prevalence of peptic ulcer disease.Aliment. Pharmacol. Ther.200929993894610.1111/j.1365‑2036.2009.03960.x19220208
     [Google Scholar]
  15. VimalaG. Gricilda ShobaF. A review on antiulcer activity of few Indian medicinal plants.Int. J. Microbiol.2014201411410.1155/2014/51959024971094
     [Google Scholar]
  16. VyawahareN. DeshmukhV. GadkariM. KagatharaV. Plants with antiulcer activity.Pharmacogn. Rev.200935118
     [Google Scholar]
  17. WormsleyKG Aetiology of ulcers.Baillière's Clinical Gastroenterology19882355557110.1016/S0950‑3528(88)80005‑8
     [Google Scholar]
  18. MalikT.F. GnanapandithanK. SinghK. Peptic Ulcer Disease.StatPearlsTreasure IslandStatPearls Publishing2024
     [Google Scholar]
  19. FichnaJ. Introduction to Gastrointestinal DiseasesSpringer : Cham201710.1007/978‑3‑319‑59885‑7
     [Google Scholar]
  20. MalfertheinerP ChanFK McCollKE Peptic ulcer disease.Lancet.2009374969914496110.1016/S0140‑6736(09)60938‑7
     [Google Scholar]
  21. TominagaK. ArakawaT. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application.J. Gastroenterol.201348445246210.1007/s00535‑013‑0788‑z23503839
     [Google Scholar]
  22. MajumdarD BebbJ AthertonJ Helicobacter pylori infection and peptic ulcers.Medicine201139315416110.1016/j.mpmed.2010.12.003
     [Google Scholar]
  23. ButiL. SpoonerE. Van der VeenA.G. RappuoliR. CovacciA. PloeghH.L. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.Proc Natl Acad Sci201110822923843
     [Google Scholar]
  24. BlaserMJ Not all Helicobacter pylori strains are created equal: should all be eliminated?The Lancet1997349905710202
     [Google Scholar]
  25. AkramM. Shahab-uddinA.A. UsmanghaniK. HannanA. MohiuddinE. AsifM.S.S. Peptic ulcer and Helicobacter pylori eradication: A review article.Int. J. Med. Sci.20102370375
     [Google Scholar]
  26. GriffinMR PiperJM DaughertyJR SnowdenM RayWA Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons.Ann Intern Med.199111442576310.7326/0003‑4819‑114‑4‑257
     [Google Scholar]
  27. ScarpignatoC HuntRH Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention.Gastroenterol Clin North Am.20103934336410.1016/j.gtc.2010.08.010
     [Google Scholar]
  28. WhittleB.J.R. Gastrointestinal effects of nonsteroidal anti-inflammatory drugs.Fundam. Clin. Pharmacol.200317330131310.1046/j.1472‑8206.2003.00135.x12803569
     [Google Scholar]
  29. AllenA FlemstromG GarnerA KivilaaksoE. Gastroduodenal mucosal protection.Physiol Rev.19937348235710.1152/physrev.1993.73.4.823
     [Google Scholar]
  30. ChoudharyA SinghA. Peptic ulcer: A review on epidemiology, molecular mechanism of pathogenesis and management..2014
     [Google Scholar]
  31. SzaboS VinczeA SandorZS JadusM GombosZ PedramA LevinE HagarJ IaquintoG Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF.Dig Dis Sci.199843940S45
     [Google Scholar]
  32. AiharaT NakamuraE AmagaseK TomitaK FujishitaT FurutaniK OkabeS Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future.Pharmacol Ther.20039811092710.1016/S0163‑7258(03)00015‑9
     [Google Scholar]
  33. JaswanthK. KumarK. VenkateshP. A review on peptic ulcer.UPI-JPMHS2022291926
     [Google Scholar]
  34. WaldumH.L. KlevelandP.M. SandvikA.K. BrennaE. SyversenU. BakkeI. TømmeråsK. The cellular localization of the cholecystokinin 2 (gastrin) receptor in the stomach.Pharmacol. Toxicol.200291635936210.1034/j.1600‑0773.2002.910613.x12688379
     [Google Scholar]
  35. SzaboS VinczeÁ. Growth factors in ulcer healing: lessons from recent studies.J Physiol Paris.2000942778110.1016/S0928‑4257(00)00146‑7
     [Google Scholar]
  36. MaloneyJ.P. SillimanC.C. AmbrusoD.R. WangJ. TuderR.M. VoelkelN.F. In vitro release of vascular endothelial growth factor during platelet aggregation.Am. J. Physiol.19982753H1054H10619724313
     [Google Scholar]
  37. JonesM.K. KawanakaH. BaatarD. SzabóI.L. TsugawaK. PaiR. KohG.Y. KimI. SarfehI.J. TarnawskiA.S. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1.Gastroenterology200112151040104710.1053/gast.2001.2930811677194
     [Google Scholar]
  38. WallaceJ.L. MillerM.J.S. Nitric oxide in mucosal defense: A little goes a long way.Gastroenterology2000119251252010.1053/gast.2000.930410930387
     [Google Scholar]
  39. BilskiJ. KonturekP.C. KonturekS.J. CieszkowskiM. CzarnobilskiK. Role of endogenous nitric oxide in the control of gastric acid secretion, blood flow and gastrin release in conscious dogs.Regul. Pept.199453317518410.1016/0167‑0115(94)90166‑X7846293
     [Google Scholar]
  40. MaL. WallaceJ.L. Endothelial nitric oxide synthase modulates gastric ulcer healing in rats.Am. J. Physiol. Gastrointest. Liver Physiol.20002792G341G34610.1152/ajpgi.2000.279.2.G34110915643
     [Google Scholar]
  41. TakeuchiT. MiuraS. WangL. UeharaK. MizumoriM. KishikawaH. HokariR. HiguchiH. AdachiM. NakamizoH. IshiiH. Nuclear factor-kappaB and TNF-α mediate gastric ulceration induced by phorbol myristate acetate.Dig. Dis. Sci.20024792070207810.1023/A:101963311485412353857
     [Google Scholar]
  42. HawkeyC.J. RamptonD.S. Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease, or treatment?Gastroenterology19858951162118810.1016/0016‑5085(85)90225‑23930341
     [Google Scholar]
  43. AsakoH KubesP WallaceJ WolfRE GrangerDN Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate.Gastroenterology199210311465210.1016/0016‑5085(92)91107‑F
     [Google Scholar]
  44. WongK. FreundK. Inhibition of the n -formylmethionyl-leucyl-phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series.Can. J. Physiol. Pharmacol.198159991592010.1139/y81‑1416271378
     [Google Scholar]
  45. JaiswalF. RaiA.K. WalP. WalA. SinghS.P. Peptic ulcer: A review on etiology, pathogenesis and treatment.Asian J. Pharm. Educ. Res202110411710.38164/AJPER/10.4.2021.1‑17
     [Google Scholar]
  46. KaliaN. BardhanK. ReedM. JacobS. BrownN. Mast cell stabilization prevents ethanol-induced rat gastric mucosal injury: Mechanisms of protection.J. Gastroenterol. Hepatol.200015213314110.1046/j.1440‑1746.2000.02064.x10735536
     [Google Scholar]
  47. OhkuraY FurihataT KawamataH TabuchiM KubotaK TeranoA SakaiT FujimoriT Evaluation of cell proliferation and apoptosis in Helicobacter pylori gastritis using an image analysis processor.Gastric Cancer20036495410.1007/s101200300006
     [Google Scholar]
  48. YanagisawaM KuriharaH KimuraS TomobeY KobayashiM MitsuiY YazakiY GotoK MasakiT. A novel potent vasoconstrictor peptide produced by vascular endothelial cells.Nature198833261634115
     [Google Scholar]
  49. PihanG. RogersC. SzaboS. Vascular injury in acute gastric mucosal damage.Dig. Dis. Sci.198833562563210.1007/BF017983683258812
     [Google Scholar]
  50. SøreideK ThorsenK HarrisonEM BingenerJ MøllerMH Ohene-YeboahM SøreideJA Perforated peptic ulcer.Lancet.2015386100001288129810.1016/S0140‑6736(15)00276‑7
     [Google Scholar]
  51. HoogerwerfW.A. PasrichaP.J. Agents used for control of gastric acidity and treatment of peptic ulcers andgastroesophageal reflux disease.The Pharmacological Basis of Therapeutics.New YorkMc Graw-Hill200610051019
     [Google Scholar]
  52. LiuJ. WangF. LuoH. LiuA. LiK. LiC. JiangY. Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms.Int. Immunopharmacol.20163017918710.1016/j.intimp.2015.11.01826604089
     [Google Scholar]
  53. AmirshahrokhiK. KhaliliA.R. Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol.Int. Immunopharmacol.20163418318810.1016/j.intimp.2016.03.00626967742
     [Google Scholar]
  54. LiuY. TianX. GouL. FuX. LiS. LanN. YinX. Protective effect of l -citrulline against ethanol-induced gastric ulcer in rats.Environ. Toxicol. Pharmacol.201234228028710.1016/j.etap.2012.04.00922634488
     [Google Scholar]
  55. DokmeciD. AkpolatM. AydogduN. DoganayL. TuranF.N. L-carnitine inhibits ethanol-induced gastric mucosal injury in rats.Pharmacol. Rep.200557448148816129915
     [Google Scholar]
  56. JiC.X. FanD.S. LiW. GuoL. LiangZ.L. XuR.M. ZhangJ.J. Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.Eur. J. Pharmacol.20126911-3465110.1016/j.ejphar.2012.06.04122789173
     [Google Scholar]
  57. BeiranvandM. A review of the most common in vivo models of stomach ulcers and natural and synthetic anti-ulcer compounds: A comparative systematic study.Phytomedicine Plus20222210026410.1016/j.phyplu.2022.100264
     [Google Scholar]
  58. PitariG. MalergueF. MartinF. PhilippeJ.M. MassucciM.T. ChabretC. MarasB. DuprèS. NaquetP. GallandF. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.FEBS Lett.20004832-314915410.1016/S0014‑5793(00)02110‑411042271
     [Google Scholar]
  59. LichtenbergerL.M. SzaboS. TrierJ.S. Duodenal ulcerogens, cysteamine and propionitrile, stimulate serum gastrin levels in the rat.Gastroenterology19777361305130810.1016/S0016‑5085(19)31505‑7913972
     [Google Scholar]
  60. SzaboS. ReynoldsE.S. LictenbergerL.M. HaithL.R.Jr DzauV.J. Pathogenesis of duodenal ulcer. Gastric hyperacidity caused by propionitrile and cysteamine in rats.Res. Commun. Chem. Pathol. Pharmacol.1977162311323847287
     [Google Scholar]
  61. LichtenbergerL.M. SzaboS. ReynoldsE.S. Gastric emptying in the rat is inhibited by the duodenal ulcerogens, cysteamine and propionitrile.Gastroenterology19777351072107610.1016/S0016‑5085(19)31860‑8908486
     [Google Scholar]
  62. SzaboS. ReichlinS. Somatostatin in rat tissues is depleted by cysteamine administration.Endocrinology198110962255225710.1210/endo‑109‑6‑22556118261
     [Google Scholar]
  63. ChoiK.S. KimE.H. HongH. OckC.Y. LeeJ.S. KimJ.H. HahmK.B. Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A 2 /5-lipoxygenase and activating γ-glutamylcysteine synthetase.J. Gastroenterol. Hepatol.201227S3132210.1111/j.1440‑1746.2012.07065.x22486866
     [Google Scholar]
  64. FukuharaS. SuzukiH. MasaokaT. ArakawaM. HosodaH. MinegishiY. KangawaK. IshiiH. KitajimaM. HibiT. Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.Am. J. Physiol. Gastrointest. Liver Physiol.20052891G138G14510.1152/ajpgi.00298.200415778430
     [Google Scholar]
  65. KhomenkoT. SzaboS. DengX. IshikawaH. AndersonG.J. McLarenG.D. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats.Am. J. Physiol. Gastrointest. Liver Physiol.20092966G1277G128610.1152/ajpgi.90257.200819342511
     [Google Scholar]
  66. ManW.K. BoesbyS. MichalowskiA. ThompsonJ. SpencerJ. Histamine, histamine formation capacity and gastrin in cysteamine-induced peptic ulcer.J. Exp. Pathol. (Oxford)1990711951042310618
     [Google Scholar]
  67. MahmoudY.I. Abd El-GhffarE.A. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation.Biomed. Pharmacother.201910931432110.1016/j.biopha.2018.10.11830396089
     [Google Scholar]
  68. OdashimaM. OtakaM. JinM. KomatsuK. WadaI. HorikawaY. MatsuhashiT. HatakeyamaN. OyakeJ. OhbaR. WatanabeS. LindenJ. Attenuation of gastric mucosal inflammation induced by aspirin through activation of A 2A adenosine receptor in rats.World J. Gastroenterol.200612456857310.3748/wjg.v12.i4.56816489670
     [Google Scholar]
  69. WangZ. HasegawaJ. WangX. MatsudaA. TokudaT. MiuraN. WatanabeT. Protective effects of ginger against aspirin-induced gastric ulcers in rats.Yonago Acta Med.2011541111924031124
     [Google Scholar]
  70. TakawaleH. MuteV. AwariD. HukkeriV.I. MehtaP. VawhalP. Screening of antiulcer activity of Caesalpinia pulcherrima L. Bark. against aspirin induced ulcer in rats.World Journal of Medical Sciences.201164168172
     [Google Scholar]
  71. GulH. AbbasK. QadirM.I. Gastro-protective effect of ethanolic extract of Mentha longifolia in alcohol- and aspirin-induced gastric ulcer models.Bangladesh J. Pharmacol.201510124124510.3329/bjp.v10i1.21689
     [Google Scholar]
  72. BakhtaouiF.Z. LakmichiH. ChaitA. GadhiC.A. In vivo Gastro-protective effects of five moroccan medicinal plants against gastric ulcer.AJPCT201421112621276
     [Google Scholar]
  73. MarhuendaE. MartinM.J. Alarcon LastraC.D.L. Antiulcerogenic activity of aescine in different experimental models.Phytother. Res.199371131610.1002/ptr.2650070105
     [Google Scholar]
  74. GargG. NigamS. OgleC. The gastric antiulcer effects of the leaves of the neem tree.Planta Med.199359321521710.1055/s‑2006‑9596548316589
     [Google Scholar]
  75. GlavinG.B. MikhailA.A. Stress and ulcer etiology in the rat.Physiol. Behav.197616213513910.1016/0031‑9384(76)90296‑17792
     [Google Scholar]
  76. AlkofahiA. AttaA.H. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats.J. Ethnopharmacol.199967334134510.1016/S0378‑8741(98)00126‑310617070
     [Google Scholar]
  77. KhazaeiM SalehiH Protective effect of of Falcaria vulgaris extract on ethanol induced gastric ulcer in rat.IJPT200651
     [Google Scholar]
  78. NagarajuB. AnandS.C. AhmedN. ChandraJ.N. AhmedF. PadmavathiG.V. Antiulcer activity of aqueous extract of Citrus medica Linn. fruit against ethanol induced ulcer in rats.Adv. Biol. Res. (Faisalabad)2012612429
     [Google Scholar]
  79. SQ.W. AA.M. HS. AA.Z. iS. Cytoprotective activities of Polygonum minus aqueous leaf extract on ethanol-induced gastric ulcer in rats.J. Med. Plants Res.20104242658266510.5897/JMPR09.412
     [Google Scholar]
  80. LiW. HuangH. NiuX. FanT. MuQ. LiH. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice.Toxicol. Appl. Pharmacol.20132721212910.1016/j.taap.2013.05.03523769714
     [Google Scholar]
  81. ByeonS. OhJ. LimJ.S. LeeJ.S. KimJ.S. Protective effects of Dioscorea batatas flesh and peel extracts against ethanol-induced gastric ulcer in mice.Nutrients20181011168010.3390/nu1011168030400615
     [Google Scholar]
  82. Al-QarawiA.A. Abdel-RahmanH. AliB.H. MousaH.M. El-MougyS.A. The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats.J. Ethnopharmacol.200598331331710.1016/j.jep.2005.01.02315814265
     [Google Scholar]
  83. PanL. TangQ. FuQ. HuB. XiangJ. QianJ. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice.Acta Pharmacol. Sin.200526111334133810.1111/j.1745‑7254.2005.00186.x16225755
     [Google Scholar]
  84. PeresF.F. LevinR. SuiamaM.A. DianaM.C. GouvêaD.A. AlmeidaV. SantosC.M. LungatoL. ZuardiA.W. HallakJ.E.C. CrippaJ.A. VâniaD.A. SilvaR.H. AbílioV.C. Cannabidiol prevents motor and cognitive impairments induced by reserpine in rats.Front. Pharmacol.2016734310.3389/fphar.2016.0034327733830
     [Google Scholar]
  85. TangY.Q. LiZ.R. ZhangS.Z. MiP. ChenD.Y. FengX.Z. Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish.Neurotoxicol. Teratol.20197610683510.1016/j.ntt.2019.10683531518687
     [Google Scholar]
  86. LeãoA.H.F.F. Sarmento-SilvaA.J. SantosJ.R. RibeiroA.M. SilvaR.H. Molecular, neurochemical, and behavioral hallmarks of reserpine as a model for Parkinson’s disease: new perspectives to a long-standing model.Brain Pathol.201525437739010.1111/bpa.1225325726735
     [Google Scholar]
  87. QianY. LiG.J. ZhuK. SuoH.Y. SunP. ZhaoX. Effects of three types of resistant starch on intestine and their gastric ulcer preventive activities in vivo.J. Korean Soc. Appl. Biol. Chem.201356673974610.1007/s13765‑013‑3229‑z
     [Google Scholar]
  88. ZhouY.L. WangR. FengX. ZhaoX. Preventive effect of insect tea against reserpine-induced gastric ulcers in mice.Exp. Ther. Med.2014841318132410.3892/etm.2014.185925187847
     [Google Scholar]
  89. YiR. WangR. SunP. ZhaoX. Antioxidant-mediated preventative effect of Dragon-pearl tea crude polyphenol extract on reserpine-induced gastric ulcers.Exp. Ther. Med.201510133834410.3892/etm.2015.247326170959
     [Google Scholar]
  90. PfeifferC.J. ChoC.H. CheemaA. SaltmanD. Reserpine-induced gastric ulcers: Protection by lysosomal stabilization due to zinc.Eur. J. Pharmacol.198061434735310.1016/0014‑2999(80)90073‑47371712
     [Google Scholar]
  91. OgleC.W. ChoC.H. Protection by zinc sulphate against reserpine-induced ulceration and other gastric effects in the rat.Pharmacology197817525426110.1159/00013686481490
     [Google Scholar]
  92. AjiboD Gastro protective effects of tadalafilon ethanol-inducedand reserpine–induced gastric ulcer in rats.IJGH2022
     [Google Scholar]
  93. NedelcuL. GrapaD. SandorV. OrbaiP. DumitrascuD.L. Inhibition of reserpine-induced ulcers by calcitonin in rats.Bulletin of the Transilvania University of Brașov.20114532197
     [Google Scholar]
  94. FriesJF. Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use.Gastroenterology19899626475
     [Google Scholar]
  95. SimmonsD.L. BottingR.M. HlaT. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.Pharmacol. Rev.200456338743710.1124/pr.56.3.315317910
     [Google Scholar]
  96. SlomianyB.L. SlomianyA. Role of endothelin-converting enzyme-1 in the suppression of constitutive nitric oxide synthase in rat gastric mucosal injury by indomethacin.Scand. J. Gastroenterol.200035111131100
     [Google Scholar]
  97. MaityB. Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice.Int. Immunopharmacol.200994491498
     [Google Scholar]
  98. SuzukiT. YoshidaN. NakabeN. IsozakiY. KajikawaH. TakagiT. HandaO. KokuraS. IchikawaH. NaitoY. MatsuiH. YoshikawaT. Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution.J. Pharmacol. Sci.2008106346947710.1254/jphs.FP007142218360096
     [Google Scholar]
  99. RajiY. OyeyemiW.A. ShittuS.T. BolarinwaA.F. Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.Niger. J. Physiol. Sci.2011261434822314986
     [Google Scholar]
  100. Abdel-RaheemI.T. Gastroprotective effect of rutin against indomethacin-induced ulcers in rats.Basic Clin. Pharmacol. Toxicol.2010107374275010.1111/j.1742‑7843.2010.00568.x20374237
     [Google Scholar]
  101. EraslanE. TanyeliA. GülerM.C. KurtN. YetimZ. Agomelatine prevents indomethacin-induced gastric ulcer in rats.Pharmacol. Rep.202072498499110.1007/s43440‑019‑00049‑232048252
     [Google Scholar]
  102. El-AshmawyN.E. KhedrE.G. El-BahrawyH.A. SelimH.M. Nebivolol prevents indomethacin-induced gastric ulcer in rats.J. Immunotoxicol.201613458058910.3109/1547691X.2016.114248827224860
     [Google Scholar]
  103. El-AshmawyN.E. KhedrE.G. El-BahrawyH.A. SelimH.M. Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats.Nutrition2016327-884985410.1016/j.nut.2016.01.01027158056
     [Google Scholar]
  104. ZaghloolS. ShehataB. Abo-SeifA. Abd El-LatifH. Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats.J. Nat. Sci. Biol. Med.20156242142810.4103/0976‑9668.16002626283843
     [Google Scholar]
  105. BhattacharyaS. ChaudhuriS.R. ChattopadhyayS. BandyopadhyayS.K. Healing properties of some Indian medicinal plants against indomethacin-induced gastric ulceration of rats.J. Clin. Biochem. Nutr.200741210611410.3164/jcbn.200701518193104
     [Google Scholar]
  106. AmerM.A. EidJ.I. HamadS.R. Evaluation of gastric and hepatic protective effects of kiwifruit extract on toxicity of indomethacin in swiss albino mice using histological studies.Int. J. Sci. Res.20143716311641
     [Google Scholar]
  107. OkabeS AmagaseK TakeuchiK Acetic acid ulcer model-state of the art in 2010.Gastroenterology2010173
     [Google Scholar]
  108. DevarajV.C. Gopala KrishnaB. ViswanathaG.L. Satya PrasadV. Vinay BabuS.N. Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats.Saudi Pharm. J.201119317117610.1016/j.jsps.2011.03.00323960756
     [Google Scholar]
  109. da SilvaL.M. PezziniB.C. SomensiL.B. Bolda MarianoL.N. MariottM. BoeingT. dos SantosA.C. LongoB. Cechinel-FilhoV. de SouzaP. de AndradeS.F. Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats.Chem. Biol. Interact.2019308455010.1016/j.cbi.2019.05.01131095933
     [Google Scholar]
  110. da SilvaL.M. AllemandA. MendesD.A.G.B. dos SantosA.C. AndréE. de SouzaL.M. CiprianiT.R. DartoraN. MarquesM.C.A. BaggioC.H. WernerM.F. Ethanolic extract of roots from Arctium lappa L. accelerates the healing of acetic acid-induced gastric ulcer in rats: Involvement of the antioxidant system.Food Chem. Toxicol.20135117918710.1016/j.fct.2012.09.02623036453
     [Google Scholar]
  111. GarabaduD. SinghS. GautamT. Manilkara hexandra (Roxb.) dubard ameliorates acetic acid-induced rat gastric ulcer.J. Diet. Suppl.202118327829210.1080/19390211.2020.177039332449638
     [Google Scholar]
  112. VianaA.F.S.C. LopesM.T.P. OliveiraF.T.B. NunesP.I.G. SantosV.G. BragaA.D. SilvaA.C.A. SousaD.P. VianaD.A. RaoV.S. OliveiraR.C.M. SantosF.A. (−)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells.Eur. J. Pharmacol.201985413914810.1016/j.ejphar.2019.04.02530991046
     [Google Scholar]
  113. WarzechaZ. DembińskiA. BrzozowskiT. CeranowiczP. DembińskiM. StachuraJ. KonturekS.J. Histamine in stress ulcer prophylaxis in rats.J. Physiol. Pharmacol.200152340742111596859
     [Google Scholar]
  114. FulgaS. PelinA.M. GhiciucC.M. LupușoruE.C. Particularities of experimental models used to induce gastric ulcer.ARS Medica Tomitana201925417918410.2478/arsm‑2019‑0035
     [Google Scholar]
  115. ShahD.I. SantaniD.D. GoswamiS.S. A novel use of methylene blue as a pharmacological tool.J. Pharmacol. Toxicol. Methods200654327327710.1016/j.vascn.2005.12.00316488629
     [Google Scholar]
  116. NaitoY. YoshikawaT. YonetaT. YagiN. MatsuyamaK. AraiM. TanigawaT. KondoM. A new gastric ulcer model in rats produced by ferrous iron and ascorbic acid injection.Digestion199556647247810.1159/0002012788536816
     [Google Scholar]
  117. FisherA.E.O. NaughtonD.P. Iron supplements: the quick fix with long-term consequences.Nutr. J.200431210.1186/1475‑2891‑3‑214728718
     [Google Scholar]
  118. PérezS. Taléns-ViscontiR. Rius-PérezS. FinamorI. SastreJ. Redox signaling in the gastrointestinal tract.Free Radic. Biol. Med.20171047510310.1016/j.freeradbiomed.2016.12.04828062361
     [Google Scholar]
  119. OkaS. OginoK. HobaraT. YoshimuraS. YanaiH. OkazakiY. TakemotoT. IshiyamaH. ImaizumiT. YamasakiK. KanbeT. Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat.Experientia199046328128310.1007/BF019517662155813
     [Google Scholar]
  120. SalimA.S. Protection against stress-induced acute gastric mucosal injury by free radical scavengers.Intensive Care Med.199117845546010.1007/BF016907661797888
     [Google Scholar]
  121. RauW. HohausC. JessenE. A differential approach to form and site of peptic ulcer.Sci. Rep.201991868310.1038/s41598‑019‑44893‑x31213634
     [Google Scholar]
  122. GuoS. GaoQ. JiaoQ. HaoW. GaoX. CaoJ.M. Gastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6.World J. Gastroenterol.201218243145315510.3748/wjg.v18.i24.314522791951
     [Google Scholar]
  123. LuS. WuD. SunG. GengF. ShenY. TanJ. SunX. LuoY. Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival.Pharm. Biol.201957177077710.1080/13880209.2019.168262031696757
     [Google Scholar]
  124. RainsfordK.D. The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice.Agents Actions1987213-431631910.1007/BF019665023687587
     [Google Scholar]
  125. Nur AzlinaM.F. QodriyahH.M.S. ChuaK.H. KamisahY. Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.World J. Gastroenterol.201723325887589410.3748/wjg.v23.i32.588728932080
     [Google Scholar]
  126. Al-GabriN. ElnagarG.M. SaghirS.A.M. El-ShaibanyA. AlnomasyS.F. AlthafarZ.M. ElkomyN.M.I.M. ElaasserM.M. AbdohM.S. YosriM. Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats.BioMed Res. Int.2022202211010.1155/2022/924678535111849
     [Google Scholar]
  127. YismawY.E. AbdelwuhabM. AmbikarD.B. YismawA.E. DerebeD. MelkamW. Phytochemical and antiulcer activity screening of seed extract of Cordia africana lam (boraginaceae) in pyloric ligated rats.Clin. Pharmacol.202012677310.2147/CPAA.S24567232636685
     [Google Scholar]
  128. DanaiP. PatelS. PandeyV. SinghP. YadavG. KumarA. AgarwalT. Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats.Phytomedicine Plus20211410012710.1016/j.phyplu.2021.100127
     [Google Scholar]
  129. RajakrishnanR. AlfarhanA.H. Al-AnsariA.M. LekshmiR. SreelakshmiR. BenilP.B. KimY.O. TackJ.C. NaS.W. KimH.J. Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats.Saudi J. Biol. Sci.20202741124112910.1016/j.sjbs.2019.12.02532256174
     [Google Scholar]
  130. Abdel-HamedA.R. Abo-ElmattyD.M. EssawyS.S. TahaM.A. HuwaitE.A. AlghamdiL. Al-GhamdiM.A. Antisecretory and antioxidative effects of the antidepressants fluvoxamine and mirtazapine on water immersion stress and pyloric ligation-induced gastric ulcer in rats.Int. J. Health Sci.2022163253435599943
     [Google Scholar]
  131. AndargieY. SisayW. MollaM. NorahunA. SinghP. Evaluation of the antiulcer activity of methanolic extract and solvent fractions of the leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in rats.Evid. Based Complement. Alternat. Med.2022202211210.1155/2022/419928435815284
     [Google Scholar]
  132. Lucena PéricoL. de Cássia dos SantosR. Peixoto RodriguesV. Vasti Alfieri NunesV. VilegasW. Machado da RochaL.R. dos SantosC. Hiruma-LimaC.A. Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia.Inflammopharmacology20223041383139410.1007/s10787‑022‑00946‑835445989
     [Google Scholar]
  133. OdukanmiO.A. SalamiA.T. AshaoluO.P. AdegokeA.G. OlaleyeS.B. Kolaviron attenuates ischemia/reperfusion injury in the stomach of rats.Appl. Physiol. Nutr. Metab.2018431303710.1139/apnm‑2017‑013828841395
     [Google Scholar]
  134. FagundesF.L. PifferG.M. PéricoL.L. RodriguesV.P. Hiruma-LimaC.A. dos SantosR.C. Chrysin modulates genes related to inflammation, tissue remodeling, and cell proliferation in the gastric ulcer healing.Int. J. Mol. Sci.202021376010.3390/ijms2103076031979417
     [Google Scholar]
  135. OharaR. PéricoL.L. RodriguesV.P. BuenoG. ZanattaA.C. Campaner dos SantosL. VilegasW. ConstatinoF.B. JustulinL.A. Hiruma-LimaC.A. Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats.J. Ethnopharmacol.202025611279310.1016/j.jep.2020.11279332240780
     [Google Scholar]
  136. SikiricP. SkrticA. GojkovicS. KrezicI. ZizekH. LovricE. SikiricS. KnezevicM. StrbeS. MilavicM. KokotA. BlagaicA.B. SeiwerthS. Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome.World J. Gastroenterol.2022281234610.3748/wjg.v28.i1.2335125818
     [Google Scholar]
  137. de Cássia dos SantosR. BonaminF. PéricoL.L. RodriguesV.P. ZanattaA.C. RodriguesC.M. SannomiyaM. dos Santos RamosM.A. BonifácioB.V. BauabT.M. TamashiroJ. da RochaL.R.M. VilegasW. Hiruma-LimaC.A. Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and anti-inflammatory activities.Biomed. Pharmacother.20191111112112310.1016/j.biopha.2018.12.13230841424
     [Google Scholar]
  138. SalamiA.T. OdukanmiO.A. FaniyanO.F. OmayoneT.P. OlaleyeS.B. Seeds of Buchholzia coriacea in diet mitigate ischemic reperfusion–induced gastric ulceration in experimental rats.J. Diet. Suppl.201815684285910.1080/19390211.2017.140454429278952
     [Google Scholar]
  139. OmayoneT.P. SalamiA.T. OlopadeJ.O. OlaleyeS.B. Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats.Life Sci.202025911827210.1016/j.lfs.2020.11827232800836
     [Google Scholar]
  140. ParmarN. DesaiJ.K. A review of the current methodology for the evaluation of gastric and duodenal anti-ulcer agents.Indian J. Pharmacol.1993253120
     [Google Scholar]
  141. MoriniG. GrandiD. Methods to measure gastric mucosal lesions in the rat.Curr. Protoc. Toxicol.2010431210.1002/0471140856.tx2102s4320967744
     [Google Scholar]
  142. KhanH.A. Computer-assisted visualization and quantitation of experimental gastric lesions in rats.J. Pharmacol. Toxicol. Methods2004492899510.1016/j.vascn.2003.10.00414990333
     [Google Scholar]
/content/journals/nemj/10.2174/0102506882348139241210080210
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Epidemiology, Pathogenesis, and Induction of Peptic Ulcer: A Comprehensive Review
NEW Emirates Medical J 5, e02506882348139 (2024); https://doi.org/10.2174/0102506882348139241210080210
/content/journals/nemj/10.2174/0102506882348139241210080210
/content/journals/nemj/10.2174/0102506882348139241210080210
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  • Article Type:     Review Article
Keyword(s): Epidemiology; H. pylori; Health issue; Medications; Non-steroidal anti-inflammatory drugs; Peptic ulcer

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