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2000
Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Introduction:

Among women of reproductive age, Polycystic Ovarian Syndrome (PCOS) is a common endocrine condition marked by insulin resistance, metabolic abnormalities, and hormonal imbalances. Infertility, irregular menstrual periods, acne, hirsutism, and obesity are among the symptoms that this illness frequently causes. Traditional PCOS therapies usually include drugs like insulin sensitizers and oral contraceptives, which can have negative side effects and might not deal with the underlying causes of the condition. This study aims to examine the etiology of PCOS and the effectiveness of natural management techniques in reducing symptoms and enhancing general health outcomes.

Aims and Objective:

The objective of this study is to comprehend the pathophysiology and underlying mechanisms of PCOS, including hormonal and metabolic factors, assess the effectiveness of natural management strategies, such as dietary changes, herbal supplements, physical activity, and lifestyle interventions, in managing symptoms, investigate the effects of particular diets and lifestyle changes on insulin sensitivity, inflammation, and hormonal balance in PCOS patients, compare natural strategies with conventional treatments to determine the advantages and disadvantages of each treatment, identify research gaps, and suggest areas for future study.

Methodology:

A thorough examination of pertinent literature, including clinical studies, randomized controlled trials, and meta-analyses published in peer-reviewed journals, was a part of the search approach. Studies on the pathophysiology of PCOS, traditional therapies, and natural management strategies were found using databases like PubMed, Scopus, and Web of Science.

Results:

The review concentrated on studies conducted within the last 15 years to guarantee that the most recent findings were included. This study intends to shed light on the possible advantages of incorporating natural methods into PCOS care by combining the available data and comprehensive treatment choices.

Conclusion:

In summary, PCOS is a common and complex disorder that affects women's health worldwide. Effective management requires knowledge of its symptoms, risk factors, and underlying mechanisms. Women can be empowered to manage PCOS better and enhance their general well-being by emphasizing a holistic approach that incorporates lifestyle changes and natural therapies.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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References

  1. AzzizR. CarminaE. DewaillyD. KandarakisD.E. MorrealeE.H.F. FutterweitW. JanssenO.E. LegroR.S. NormanR.J. TaylorA.E. WitchelS.F. The androgen excess and PCOS society criteria for the polycystic ovary syndrome: The complete task force report.Fertil. Steril.200991245648810.1016/j.fertnstert.2008.06.03518950759
     [Google Scholar]
  2. AsmabiM.A. JitheshM.K. Ayurveda management of infertility associated with poly cystic ovarian syndrome: A case report.J. Ayurveda Integr. Med.202213210051310.1016/j.jaim.2021.08.00634980524
     [Google Scholar]
  3. LashenH. Review: Role of metformin in the management of polycystic ovary syndrome.Ther. Adv. Endocrinol. Metab.20101311712810.1177/204201881038021523148156
     [Google Scholar]
  4. KafaliH. IriadamM. OzardalıI. DemirN. Letrozole-induced polycystic ovaries in the rat: A new model for cystic ovarian disease.Arch. Med. Res.200435210310810.1016/j.arcmed.2003.10.00515010188
     [Google Scholar]
  5. PundirC.S. DeswalR. NarwalV. DangA. The prevalence of polycystic ovary syndrome: A brief systematic review.J. Hum. Reprod. Sci.202013426127110.4103/jhrs.JHRS_95_1833627974
     [Google Scholar]
  6. BharathiV.R. SwethaS. NeerajaaJ. MadhavicaV.J. JananiD.M. RekhaS.N. SR. BU. An epidemiological survey: Effect of predisposing factors for PCOS in Indian urban and rural population.Middle East Fertil. Soc. J.201722431331610.1016/j.mefs.2017.05.007
     [Google Scholar]
  7. AllahbadiaG.N. MerchantR. Polycystic ovary syndrome and impact on health.Middle East Fertil. Soc. J.2011161193710.1016/j.mefs.2010.10.002
     [Google Scholar]
  8. PasqualiR. VictorinS.E. YildizB.O. DulebaA.J. HoegerK. MasonH. HomburgR. HickeyT. FranksS. TapanainenJ.S. BalenA. AbbottD.H. KandarakisD.E. LegroR.S. PCOS Forum: Research in polycystic ovary syndrome today and tomorrow.Clin. Endocrinol.201174442443310.1111/j.1365‑2265.2010.03956.x21158892
     [Google Scholar]
  9. ScicchitanoP. DentamaroI. CarbonaraR. BulzisG. DachilleA. CaputoP. RiccardiR. LocorotondoM. MandurinoC. CicconeM. Cardiovascular risk in women with PCOS.Int. J. Endocrinol. Metab.201210461161810.5812/ijem.402023843832
     [Google Scholar]
  10. AminiL. TehranianN. MovahedinM. TehraniR.F. ZiaeeS. Antioxidants and management of polycystic ovary syndrome in Iran: A systematic review of clinical trials.Iran. J. Reprod. Med.20151311825653669
     [Google Scholar]
  11. SedighiS. AkbariA.A.S. AfrakhtehM. EstekiT. MajdA.H. MahmoodiZ. Comparison of lifestyle in women with polycystic ovary syndrome and healthy women.Glob. J. Health Sci.20147122823410.5539/gjhs.v7n1p22825560358
     [Google Scholar]
  12. SiriwardeneD.S.A. KarunathilakaL.P.A. KodituwakkuN.D. KarunarathneY.A.U.D. Clinical efficacy of Ayurveda treatment regimen on Subfertility with poly cystic ovarian syndrome (PCOS).Ayu2010311242710.4103/0974‑8520.6820322131680
     [Google Scholar]
  13. GoswamiP.K. KhaleA. OgaleS. Natural remedies for polycystic ovarian syndrome (PCOS): A review.Int J Pharm Phytopharmacol Res.201216396402
     [Google Scholar]
  14. ZhaoX. NiR. LiL. MoY. HuangJ. HuangM. AzzizR. YangD. Defining hirsutism in Chinese women: A cross-sectional study.Fertil. Steril.201196379279610.1016/j.fertnstert.2011.06.04021762890
     [Google Scholar]
  15. QaidM.M. AbdelrahmanM.M. Role of insulin and other related hormones in energy metabolism—A review.Cogent Food Agric.201621126769110.1080/23311932.2016.1267691
     [Google Scholar]
  16. NidhiR. PadmalathaV. NagarathnaR. RamA. Effect of a yoga program on glucose metabolism and blood lipid levels in adolescent girls with polycystic ovary syndrome.Int. J. Gynaecol. Obstet.20121181374110.1016/j.ijgo.2012.01.02722507264
     [Google Scholar]
  17. UnluhizarciK. KaracaZ. KelestimurF. Role of insulin and insulin resistance in androgen excess disorders.World J. Diabetes202112561662910.4239/wjd.v12.i5.61633995849
     [Google Scholar]
  18. CussenL. McDonnellT. BennettG. ThompsonC.J. SherlockM. O’ReillyM.W. Approach to androgen excess in women: Clinical and biochemical insights.Clin. Endocrinol.202297217418610.1111/cen.1471035349173
     [Google Scholar]
  19. KwonC.Y. ChoI.H. ParkK.S. Therapeutic effects and mechanisms of herbal medicines for treating polycystic ovary syndrome: A review.Front. Pharmacol.202011119210.3389/fphar.2020.0119232903374
     [Google Scholar]
  20. CappelliV. MusacchioM.C. BulfoniA. MorganteG. LeoD.V. Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS.Eur. Rev. Med. Pharmacol. Sci.2017212152928724177
     [Google Scholar]
  21. KwonC.Y. LeeB. ParkK.S. Oriental herbal medicine and moxibustion for polycystic ovary syndrome.Medicine20189743e1294210.1097/MD.000000000001294230412108
     [Google Scholar]
  22. BalenA. The pathophysiology of polycystic ovary syndrome: Trying to understand PCOS and its endocrinology.Best Pract. Res. Clin. Obstet. Gynaecol.200418568570610.1016/j.bpobgyn.2004.05.00415380141
     [Google Scholar]
  23. KumarapeliV. SeneviratneR.A. WijeyaratneC.N. YapaR.M.S.C. DodampahalaS.H. A simple screening approach for assessing community prevalence and phenotype of polycystic ovary syndrome in a semi-urban population in Sri Lanka.Am. J. Epidemiol.2008168332132810.1093/aje/kwn13718550559
     [Google Scholar]
  24. NautiyalH. ImamS.S. AlshehriS. GhoneimM.M. AfzalM. AlzareaS.I. GüvenE. AbbasiA.F.A. KazmiI. Polycystic ovarian syndrome: A complex disease with a genetics approach.Biomedicines202210354010.3390/biomedicines1003054035327342
     [Google Scholar]
  25. GargD. TalR. The role of AMH in the pathophysiology of polycystic ovarian syndrome.Reprod. Biomed. Online2016331152810.1016/j.rbmo.2016.04.00727174394
     [Google Scholar]
  26. BegumGS ShariffA AymanG MohammadB HousamR KhaledN Assessment of risk factors for development of polycystic ovarian syndrome.Diabetes201741164167
     [Google Scholar]
  27. PelluriR. SrikanthK. ParitalaH. RaviV. KammaM.S.P. PidugurallaK.D. VenkateswarluU. SubrahmanyamJ. BannaravuriK. ThungaT. VemparalaR. DoddapaneniS. AvulamandaN. SivaniV. PuttaguntaS. The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients.Clin. Epidemiol. Glob. Health20211210091010.1016/j.cegh.2021.100910
     [Google Scholar]
  28. O’ReillyM. GathercoleL. CapperF. ArltW. TomlinsonJ. Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome.Lancet2015385S1610.1016/S0140‑6736(15)60331‑226312838
     [Google Scholar]
  29. MalikS. SaeedS. SaleemA. KhanM.I. KhanA. AkhtarM.F. Alternative treatment of polycystic ovary syndrome: Pre-clinical and clinical basis for using plant-based drugs.Front. Endocrinol.202414129440610.3389/fendo.2023.129440638725974
     [Google Scholar]
  30. ArentzS. AbbottJ.A. SmithC.A. BensoussanA. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; A review of the laboratory evidence for effects with corroborative clinical findings.BMC Complement. Altern. Med.201414151110.1186/1472‑6882‑14‑51125524718
     [Google Scholar]
  31. NormanR.J. DewaillyD. LegroR.S. HickeyT.E. Polycystic ovary syndrome.Lancet2007370958868569710.1016/S0140‑6736(07)61345‑217720020
     [Google Scholar]
  32. KhanageS.G. SubhashT.Y. BhaiyyasahebI.R. Herbal drugs for the treatment of polycystic ovary syndrome (PCOS) and its complications.Pharm. Res.20192151331823112
     [Google Scholar]
  33. DunneN. The natural diet solution for PCOS and Infertility: How to manage polycystic ovary syndrome naturally.Natural Solutions for PCOS2006
     [Google Scholar]
  34. LegroR.S. BarnhartH.X. SchlaffW.D. CarrB.R. DiamondM.P. CarsonS.A. SteinkampfM.P. CoutifarisC. McGovernP.G. CataldoN.A. GosmanG.G. NestlerJ.E. GiudiceL.C. LeppertP.C. MyersE.R. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.N. Engl. J. Med.2007356655156610.1056/NEJMoa06397117287476
     [Google Scholar]
  35. ArmaniniD. CastelloR. ScaroniC. BonanniG. FacciniG. PellatiD. BertoldoA. FioreC. MoghettiP. Treatment of polycystic ovary syndrome with spironolactone plus licorice.Eur. J. Obstet. Gynecol. Reprod. Biol.20071311616710.1016/j.ejogrb.2006.10.01317113210
     [Google Scholar]
  36. FelembanA. TanS.L. TulandiT. Laparoscopic treatment of polycystic ovaries with insulated needle cautery: A reappraisal.Fertil. Steril.200073226626910.1016/S0015‑0282(99)00534‑810685526
     [Google Scholar]
  37. AbasianZ. RostamzadehA. MohammadiM. HosseiniM. kopaeiR.M. A review on role of medicinal plants in polycystic ovarian syndrome: Pathophysiology, neuroendocrine signaling, therapeutic status and future prospects.Middle East Fertil. Soc. J.201823425526210.1016/j.mefs.2018.04.005
     [Google Scholar]
  38. TilburtJ.C. KaptchukT.J. Herbal medicine research and global health: An ethical analysis.Bullet. World Health Org.200886859459910.2471/BLT.07.042820
     [Google Scholar]
  39. GanieM. VasudevanV. WaniI. BabaM. ArifT. RashidA. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India.Indian J. Med. Res.2019150433334410.4103/ijmr.IJMR_1937_1731823915
     [Google Scholar]
  40. StankiewiczM. NormanR. Diagnosis and management of polycystic ovary syndrome: A practical guide.Drugs200666790391210.2165/00003495‑200666070‑0000216740005
     [Google Scholar]
  41. KandarakisD.E. BaillargeonJ.P. IuornoM.J. JakubowiczD.J. NestlerJ.E. A modern medical quandary: Polycystic ovary syndrome, insulin resistance, and oral contraceptive pills.J. Clin. Endocrinol. Metab.20038851927193210.1210/jc.2002‑02152812727935
     [Google Scholar]
  42. HalikiasI. LytrasA. SyriouV. TolisG. Combined oral contraceptives and gonadotropin releasing hormone agonistic analogs in polycystic ovary syndrome: Clinical and experimental studies.Eur. J. Contracept. Reprod. Health Care19972421322410.3109/136251897091652979678076
     [Google Scholar]
  43. BarbieriR.L. Metformin for the treatment of polycystic ovary syndrome.Obstet. Gynecol.2003101478579310.1016/S0029‑7844(03)00045‑012681887
     [Google Scholar]
  44. ChristyN.A. FranksA.S. CrossL.B. Spironolactone for hirsutism in polycystic ovary syndrome.Ann. Pharmacother.20053991517152110.1345/aph.1G02516076921
     [Google Scholar]
  45. RodinD.A. BanoG. BlandJ.M. TaylorK. NusseyS.S. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women.Clin. Endocrinol.1998491919910.1046/j.1365‑2265.1998.00492.x9797852
     [Google Scholar]
  46. OngM. PengJ. JinX. QuX. Chinese herbal medicine for the optimal management of polycystic ovary syndrome.Am. J. Chin. Med.201745340542210.1142/S0192415X1750025228359195
     [Google Scholar]
  47. KambleAV DhamaneSP KulkarniAS PotnisVV Review on effects of herbal extract for the treatment of polycystic ovarian syndrome (PCOS).Plant Arch.202020111891195
     [Google Scholar]
  48. GadeR. DwarampudiL.P. DharshiniS.P. RajR.K. Polycystic ovarian syndrome (PCOS): Approach to traditional systems, natural and bio-chemical compounds for its management.Indian J. Biochem. Biophys.2022595521527
     [Google Scholar]
  49. JungbauerA. MedjakovicS. Phytoestrogens and the metabolic syndrome.J. Steroid Biochem. Mol. Biol.201413927728910.1016/j.jsbmb.2012.12.00923318879
     [Google Scholar]
  50. ManouchehriA. AbbaszadehS. AhmadiM. NejadF.K. BahmaniM. DastyarN. Polycystic ovaries and herbal remedies: A systematic review.JBRA Assist. Reprod.2023271859135916457
     [Google Scholar]
  51. SasikalaS.L. ShamilaS. A novel Ayurvedic medicine-Asokarishtam in the treatment of LETROZOLE induced PCOS in rat.J. Cell Tissue Res.2009921903
     [Google Scholar]
  52. JazaniM.A. AzgomiD.N.H. AzgomiD.N.A. AzgomiD.N.R. A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS).Daru201927286387710.1007/s40199‑019‑00312‑031741280
     [Google Scholar]
  53. KumarapeliM. KarunagodaK.P. PereraP.K. A randomized clinical trial to evaluate the efficacy of Satapushpashatavari powered drug with Satapushpa-shatavari grita for the management of polycystic ovary syndrome (PCOS).IJPSR20189624942499
     [Google Scholar]
  54. MokaberinejadR. RampishehZ. AliaslJ. AkhtariE. The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: A randomised clinical trial.J. Obstet. Gynaecol.201939565265810.1080/01443615.2018.154123230856025
     [Google Scholar]
  55. BorzoeiA. RafrafM. NiromaneshS. FarzadiL. NarimaniF. DoostanF. Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome.J. Tradit. Complement. Med.20188112813310.1016/j.jtcme.2017.04.00829322000
     [Google Scholar]
  56. AllahdadianM. TehraniH.G. ZarreF. RanjbarH. AllahdadianF. Effect of green tea on metabolic and hormonal aspect of polycystic ovarian syndrome in overweight and obese women suffering from polycystic ovarian syndrome: A clinical trial.J. Educ. Health Promot.2017613610.4103/jehp.jehp_67_1528584836
     [Google Scholar]
  57. SwaroopA. JaipuriarA.S. GuptaS.K. BagchiM. KumarP. PreussH.G. BagchiD. Efficacy of a novel fenugreek seed extract (Trigonella foenum-graecum, FurocystTM) in polycystic ovary syndrome (PCOS).Int. J. Med. Sci.2015121082583110.7150/ijms.1302426516311
     [Google Scholar]
  58. DouL. ZhengY. LiL. GuiX. ChenY. YuM. GuoY. The effect of cinnamon on polycystic ovary syndrome in a mouse model.Reprod. Biol. Endocrinol.20181619910.1186/s12958‑018‑0418‑y30340496
     [Google Scholar]
  59. GrantP. Spearmint herbal tea has significant anti‐androgen effects in polycystic ovarian syndrome. A randomized controlled trial.Phytother. Res.201024218618810.1002/ptr.290019585478
     [Google Scholar]
  60. MamaghaniE.M. AslS.M. PirouzpanahS. JafarabadiA.M. Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: A randomized controlled clinical trial.J. Obstet. Gynaecol. Res.20144041067107610.1111/jog.1231124612081
     [Google Scholar]
  61. NaeimiSA HajimehdipoorH SaberS Comparing the effect of Nigella sativa oil soft gel and placebo on oligomenorrhea, amenorrhea and laboratory characteristics in patients with polycystic ovarian syndrome, a randomized clinical trial.Res. J. Pharm.2020714959
     [Google Scholar]
  62. FanC.W. HutchersonC.N.E. HutchersonT.C. Systematic review of black cohosh (Cimicifuga racemosa) for management of polycystic ovary syndrome-related infertility.J. Pharm. Pract.202235699199910.1177/0897190021101224433926292
     [Google Scholar]
  63. AzouzA.A. AliS.E. ElsalamA.R.M. EmamS.R. GalalM.K. ElmosalamyS.H. AlsherbinyM.A. HassanB.B. LiC.G. BadawyE.S.A. Modulation of steroidogenesis by Actaea racemosa and vitamin C combination, in letrozole induced polycystic ovarian syndrome rat model: Promising activity without the risk of hepatic adverse effect.Chin. Med.20211613610.1186/s13020‑021‑00444‑z33926485
     [Google Scholar]
  64. ZengL.H. RanaS. HussainL. AsifM. MehmoodM.H. ImranI. YounasA. MahdyA. JoufiA.F.A. AbedS.N. Polycystic ovary syndrome: A disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies.Front. Pharmacol.20221387491410.3389/fphar.2022.87491435924049
     [Google Scholar]
  65. SoumyaV. MuzibY.I. VenkateshP. A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease.Indian J. Pharmacol.201648216216710.4103/0253‑7613.17883327127318
     [Google Scholar]
  66. NampoothiriL.P. DesaiB.N. MaharjanR.H. Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model.Pharmacognosy Res.20124210911510.4103/0974‑8490.9473622518083
     [Google Scholar]
  67. NampoothiriL. MaharjanR. NagarP.S. Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model.J. Ayurveda Integr. Med.20101427327910.4103/0975‑9476.7409021731374
     [Google Scholar]
  68. ShanbhagT. ShresthaJ. ShenoyS. AmuthanA. PrabhuK. SharmaS. BanerjeeS. KafleS. Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats.Indian J. Pharmacol.201042530631110.4103/0253‑7613.7035021206624
     [Google Scholar]
  69. DhanalakshmiS. DhivyaC. A perspective studies on herbalism for the preventive of PCOS.Res. J. Pharm. Technol.201811125417542410.5958/0974‑360X.2018.00989.7
     [Google Scholar]
  70. LimS.S. HutchisonS.K. RyswykV.E. NormanR.J. TeedeH.J. MoranL.J. Lifestyle changes in women with polycystic ovary syndrome.Cochrane Libr.201920193CD00750610.1002/14651858.CD007506.pub430921477
     [Google Scholar]
  71. RatheeP. RatheeS. A review of polycystic ovarian syndrome in ayurveda.Int. Res. J. Ayurveda Yoga20225211411710.47223/IRJAY.2022.5220
     [Google Scholar]
  72. Soni Morphology, phytochemistry and pharmacological potential of Asparagus racemosus.World J. Pharm. Res. Technol.2022113101117
     [Google Scholar]
  73. FarkhadA.S. KhazaliH. Therapeutic effects of isoflavone-aglycone fraction from soybean ( Glycine max L. Merrill) in rats with estradiol valerate-induced polycystic ovary syndrome as an inflammatory state.Gynecol. Endocrinol.201935121078108310.1080/09513590.2019.162471531185755
     [Google Scholar]
  74. ZhouJ. BarryJ.A. PanJ.X. WangF.F. FuZ.Z. HardimanP.J. DuezP. QuF. An atractylodes macrocephala koidz extract alleviates hyperandrogenism of polycystic ovarian syndrome.Int. J. Clin. Exp. Med.20169227582767
     [Google Scholar]
  75. SankhwarP. JaiswarS.P. YadavS. AwasthiV. GoelA. KumarP. BanikS.P. BagchiM. BagchiD. Beneficial effects of a novel fenugreek seed extract (Trigonella foenum-graecum, furocyst) in women with polycystic ovary syndrome (PCOS): A follow-up compliance clinical investigation.J. Am. Nutr. Assoc.202342769169910.1080/27697061.2022.214552636441141
     [Google Scholar]
  76. HaradaM. Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research.Reprod. Med. Biol.2022211e1248710.1002/rmb2.1248736310656
     [Google Scholar]
  77. Zanzibar Traditional and Alternative Medicine Policy Ministry of Health and Social Welfare in Collaboration with.World Health Organization2008
     [Google Scholar]
  78. GhafurniyanH. AzarniaM. NabiuniM. KarimzadehL. The effect of green tea extract on reproductive improvement in estradiol valerate-induced polycystic ovarian syndrome in rat.Iran. J. Pharm. Res.20151441215123326664389
     [Google Scholar]
  79. AlaeeS. BagheriM.J. AtaabadiM.S. KoohpeymaF. Capacity of Mentha spicata (spearmint) extracts in alleviating hormonal and folliculogenesis disturbances in a polycystic ovarian syndrome rat model. World’s.Vet. J.20203451456
     [Google Scholar]
  80. ElsheikhM. MurphyC. Polycystic ovary syndrome.Oxford University Press200810.1093/oso/9780199213689.001.0001
     [Google Scholar]
  81. FaridehZ.Z. BagherM. AshrafA. AkramA. KazemM. Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome.J. Reprod. Infertil.201011316917423926485
     [Google Scholar]
  82. NovakovicS. JakovljevicV. JovicN. AndricK. MilinkovicM. AnicicT. PindovicB. KarevaE.N. FisenkoV.P. DimitrijevicA. JovicJ.J. Exploring the antioxidative effects of ginger and cinnamon: A comprehensive review of evidence and molecular mechanisms involved in polycystic ovary syndrome (PCOS) and other oxidative stress-related disorders.Antioxidants202413439210.3390/antiox1304039238671840
     [Google Scholar]
  83. WalA WalP SaraswatN WadhwaS. A detailed review on herbal treatments for treatment of PCOS-polycystic ovary syndrome (PCOS).Curr. Nut.202122174266597860266621080509210310.2174/2665978602666210805092103
     [Google Scholar]
  84. AlwanS.H. SaeedA.M.H. Biosynthesized silver nanoparticles (using Cinnamomum zeylanicum bark extract) improve the fertility status of rats with polycystic ovarian syndrome.Biocatal. Agric. Biotechnol.20213810221710.1016/j.bcab.2021.102217
     [Google Scholar]
  85. SoumyaV. MuzibY.I. VenkateshP. HariprasathK. GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats.Chin. J. Nat. Med.201412967768410.1016/S1875‑5364(14)60103‑525263979
     [Google Scholar]
  86. LimaE.B.C. SousaC.N.S. MenesesL.N. XimenesN.C. JúniorS.M.A. VasconcelosG.S. LimaN.B.C. PatrocínioM.C.A. MacedoD. VasconcelosS.M.M. Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review.Braz. J. Med. Biol. Res.2015481195396410.1590/1414‑431x2015477326292222
     [Google Scholar]
  87. AzinF. KhazaliH. Phytotherapy of polycystic ovary syndrome: A review.Int. J. Reprod. Biomed.2022201132010.18502/ijrm.v20i1.1040435308325
     [Google Scholar]
  88. ShoaibinobarianN. EslamianG. NoormohammadiM. MalekS. RouhaniS. MirmohammadaliS.N. Dietary total antioxidant capacity and risk of polycystic ovary syndrome: A case-control study.Int. J. Fertil. Steril.202216320020510.22074/ijfs.2021.526579.110736029057
     [Google Scholar]
  89. KootiW. MoradiM. AkbariA.S. AhvaziS.N. SamaniA.M. LarkyA.D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review.J. HerbMed Pharm.20154119
     [Google Scholar]
  90. MahboubiM. Foeniculum vulgare as valuable plant in management of women’s health.J. Menopausal Med.201925111410.6118/jmm.2019.25.1.131080784
     [Google Scholar]
  91. SadrefozalayiS. FarokhiF. Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats.Avicenna J. Phytomed.20144211011725050308
     [Google Scholar]
  92. KhosrowpourZ. FahimiS. FaiziM. ShaabanZ. TansazM. SahranavardS. Evaluation of formulated herbal syrup (Containing Fennel, Anise, and Celery) on the letrozole-induced polycystic ovary syndrome model.Jundishapur J. Nat. Pharm. Prod.2022172e12081410.5812/jjnpp‑120814
     [Google Scholar]
  93. EivariA.S.H. MoghimianM. SoltaniM. ShooreiH. AsghariR. HajizadehH. ShokoohiM. AlamiS. GhaderiK.F. The effect of Galega officinalis on hormonal and metabolic profile in a rat model of polycystic ovary syndrome.Int. J. Women’s Health Reprod. Sci.20176327628210.15296/ijwhr.2018.46
     [Google Scholar]
  94. EsmaeilinezhadZ. BabajafariS. SohrabiZ. EskandariM.H. AmooeeS. BoldajiB.R. Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial.Nutr. Metab. Cardiovasc. Dis.201929220120810.1016/j.numecd.2018.07.00230538082
     [Google Scholar]
  95. RajanR.K. MS.S.K. BalajiB. Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism.Pharm. Biol.201755124225110.1080/13880209.2016.125842527927075
     [Google Scholar]
  96. ArmaniniD. MattarelloM.J. FioreC. BonanniG. ScaroniC. SartoratoP. PalermoM. Licorice reduces serum testosterone in healthy women.Steroids20046911-1276376610.1016/j.steroids.2004.09.00515579328
     [Google Scholar]
  97. YangH. KimH.J. PyunB.J. LeeH.W. Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats.Integr. Med. Res.20187326427010.1016/j.imr.2018.05.00330271715
     [Google Scholar]
  98. ShuidA.N. PingL.L. MuhammadN. MohamedN. SoelaimanI.N. The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis.J. Ethnopharmacol.2011133253854210.1016/j.jep.2010.10.03320971181
     [Google Scholar]
  99. NapoliD.A. ZucchettiP. A comprehensive review of the benefits of Taraxacum officinale on human health.Bull. Natl. Res. Cent.202145111010.1186/s42269‑021‑00567‑1
     [Google Scholar]
  100. ManneråsL. FazlianaM. NazaimoonW.W.M. LönnM. GuH.F. ÖstensonC.G. VictorinS.E. Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome.J. Ethnopharmacol.2010127234635110.1016/j.jep.2009.10.03219883744
     [Google Scholar]
  101. GonzalesG.F. CórdovaA. VegaK. ChungA. VillenaA. GóñezC. Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men.J. Endocrinol.2003176116316810.1677/joe.0.176016312525260
     [Google Scholar]
  102. MeissnerH. BilinskaR.H. MsciszA. KedziaB. Therapeutic effects of pre-gelatinized maca (Lepidium peruvianum Chacon) used as a non-hormonal alternative to hrt in perimenopausal women - clinical pilot study.Int. J. Biomed. Sci.20062214315910.59566/IJBS.2006.214323674976
     [Google Scholar]
  103. YaquettoD.E. AparicioV.M. GonzalesG.F. The antioxidant effect of Peruvian maca (Lepidium meyenii).InToxicology.Academic Press202151952510.1016/B978‑0‑12‑819092‑0.00050‑9
     [Google Scholar]
  104. RommA. Botanical medicine for women’s health E-book: Botanical medicine for women’s health E-book.Elsevier Health Sciences2017
     [Google Scholar]
  105. MokhtariM. EbrahimpoorM.R. HarfshenoS. The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome.Med. Sci. J. Islam. Azad Uni. Tehran Med. Branch20142427480
     [Google Scholar]
  106. AtaabadiS.M. AlaeeS. BagheriM.J. BahmanpoorS. Role of essential oil of Mentha spicata (Spearmint) in addressing reverse hormonal and folliculogenesis disturbances in a polycystic ovarian syndrome in a rat model.Adv. Pharm. Bull.20177465165410.15171/apb.2017.07829399556
     [Google Scholar]
  107. IervolinoM. LeporeE. ForteG. LaganàA.S. BuzzaccariniG. UnferV. Natural molecules in the management of polycystic ovary syndrome (PCOS): An analytical review.Nutrients2021135167710.3390/nu1305167734063339
     [Google Scholar]
  108. TamilselviS NaliniSJ Int. J. Res. Pharm. Sci.
     [Google Scholar]
  109. SatapathyS. DasN. BandyopadhyayD. MahapatraS.C. SahuD.S. MedaM. Effect of Tulsi (Ocimum sanctum Linn.) supplementation on metabolic parameters and liver enzymes in young overweight and obese subjects.Indian J. Clin. Biochem.201732335736310.1007/s12291‑016‑0615‑428811698
     [Google Scholar]
  110. CohenM. Tulsi - Ocimum sanctum: A herb for all reasons.J. Ayurveda Integr. Med.20145425125910.4103/0975‑9476.14655425624701
     [Google Scholar]
  111. PrakashP. GuptaN. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review.Indian J. Physiol. Pharmacol.200549212513116170979
     [Google Scholar]
  112. PachiappanS. MatheswaranS. SaravananP.P. MuthusamyG. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research.Int. J. Herb. Med.2017527880
     [Google Scholar]
  113. HuseinH.I. TukanS. AlkazalehF. The effect of marjoram ( O riganum majorana ) tea on the hormonal profile of women with polycystic ovary syndrome: A randomised controlled pilot study.J. Hum. Nutr. Diet.201629110511110.1111/jhn.1229025662759
     [Google Scholar]
  114. WangJ.G. AndersonR.A. GrahamG.M.III ChuM.C. SauerM.V. GuarnacciaM.M. LoboR.A. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: A pilot study.Fertil. Steril.200788124024310.1016/j.fertnstert.2006.11.08217296187
     [Google Scholar]
  115. ZambareK.K. ThalkariA.B. TourN.S. ReddyK.V. Herbal remedies for treatment of polycystic ovary syndrome.Asian J. Pharm. Technol.20199211211410.5958/2231‑5713.2019.00019.9
     [Google Scholar]
  116. PoornimaR. SaranyaP. BhuvaneshwariS. AveralH.I. Evaluation of Pergularia daemia and metformin in the treatment of PCOS in testosterone propionate induced albino wistar rats (Rattus norvegicus).Int J Sci Res Pub.20155503509
     [Google Scholar]
  117. OlabisiF.FJ KomolafeMO OladoyeO AlabiTS Safety evaluation of ethanolic extract of Parquetina nigrescens leaves (Afzel.) on selected tissues in letrozole-induced polycystic ovarian syndrome rats.MUJAST202222714
     [Google Scholar]
  118. ShehzadM. RasheedH. NaqviS.A. KhayriA.J.M. LorenzoJ.M. AlaghbariM.A. ManzoorM.F. AadilR.M. Therapeutic potential of date palm against human infertility: A review.Metabolites202111640810.3390/metabo1106040834205817
     [Google Scholar]
  119. JashniK.H. JahromiK.H. BagheriZ. The effect of palm pollen extract on polycystic ovary syndrome (POS) in rats.Int. J. Med. Res. Health Sci.201655317321
     [Google Scholar]
  120. HosseinK. LeilaK. EbrahimT. NazaninS. FarzadP. ElhamR. MohammadP. ZahraH. The effect of pomegranate juice extract on hormonal changes of female Wistar rats caused by polycystic ovarian syndrome.Biomed. Pharmacol. J.20158297197710.13005/bpj/849
     [Google Scholar]
  121. AshkarF. EftekhariH.M. TanidehN. KoohpeymaF. MokhtariM. IrajieC. IrajiA. Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study.Int. J. Reprod. Biomed.202018863765010.18502/ijrm.v13i8.750532923930
     [Google Scholar]
  122. HayekE.S. BitarL. HamdarL.H. MirzaF.G. DaoudG. Polycystic ovarian syndrome: An updated overview.Front. Physiol.20167112412810.3389/fphys.2016.0012427092084
     [Google Scholar]
  123. NoroozzadehM. GandevaniB.S. VakiliZ.A. TehraniR.F. Hormone-induced rat model of polycystic ovary syndrome: A systematic review.Life Sci.201719125927210.1016/j.lfs.2017.10.02029055801
     [Google Scholar]
  124. BajpaiN. RoyA. SenB. Polycystic ovarian syndrome and endometrial receptivity current perspectives and solution through Ayurveda: A review.Int. J. Res. Ayush Allied Syst.2023104263510.47070/ayushdhara.v10i4.1299
     [Google Scholar]
  125. ChandrasekaranC. Herbal approach for obesity management.Amer. J. Plant Sci.2012310031014
     [Google Scholar]
  126. DeviM.S. MuralidharanP.M. HariR. LavanyaM. AbiraamavalliT.A. PCOS modulatory activity of tinospora cordifolia leaves–An in silico approach.Biomed. Pharmacol. J.20211431125113110.13005/bpj/2215
     [Google Scholar]
  127. SultanaS. AkhterN. AkramM. ShahS.M. MunirN. RiazM. Prevalence, symptomatology and herbal management of polycystic ovarian syndrome.Alternative Medicine-UpdateIntechOpen2020
     [Google Scholar]
  128. LakshmiJ.N. BabuA.N. KiranS.S.M. NoriL.P. HassanN. AshamesA. BhandareR.R. ShaikA.B. Herbs as a source for the treatment of polycystic ovarian syndrome: A systematic review.BioTech2023121410.3390/biotech1201000436648830
     [Google Scholar]
  129. BashtianH.M. EmamiS.A. MousavifarN. EsmailyH.A. MahmoudiM. PoorM.A.H. Evaluation of fenugreek (Trigonella foenum-graceum L.), effects seeds extract on insulin resistance in women with polycystic ovarian syndrome.Iran. J. Pharm. Res.201312247548124250624
     [Google Scholar]
  130. FeyzollahiZ. KouchesfehaniM.H. JalaliH. EsfahaniE.D. HosseiniS.A. Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome.Avicenna J. Phytomed.202111329230134046325
     [Google Scholar]
  131. PoojariP. ParamanyaA. SinghD. AliA. Polycystic ovarian syndrome: Causes and therapies by herbal medicine.In Herbal Medicines Academic Press202243545110.1016/B978‑0‑323‑90572‑5.00028‑7
     [Google Scholar]
  132. ShrivastavaR. MishraS. SinghR. ShrivastavaP. Effect of integrated approach of yoga and naturopathy on polycystic ovarian syndrome: A case study.J. Family Med. Prim. Care20221141525152710.4103/jfmpc.jfmpc_651_2135516692
     [Google Scholar]
  133. AkhtarP. YardiS. AkhtarM. Effects of yoga on functional capacity and well being.Int. J. Yoga201361767910.4103/0973‑6131.10595223439856
     [Google Scholar]
  134. ArentzS. SmithC.A. AbbottJ. FaheyP. CheemaB.S. BensoussanA. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): A randomized controlled trial.Phytother. Res.20173191330134010.1002/ptr.585828685911
     [Google Scholar]
  135. WuH. ZhaoB. YaoQ. KangJ. Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes.J. Ovarian Res.202316120710.1186/s13048‑023‑01299‑837880784
     [Google Scholar]
/content/journals/nemj/10.2174/0102506882339236250105165820
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Exploring the Intricacies of Polycystic Ovarian Syndrome (PCOS): A Comprehensive Review-from Prevalence to Natural Solutions
NEW Emirates Medical J 5, e02506882339236 (2024); https://doi.org/10.2174/0102506882339236250105165820
/content/journals/nemj/10.2174/0102506882339236250105165820
/content/journals/nemj/10.2174/0102506882339236250105165820
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  • Article Type:     Review Article
Keyword(s): Herbal plants; Hormonal imbalance; Infertility; Natural Solutions; Polycystic ovarian syndrome (PCOS); Puberty

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