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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Biotransformation of Vulgarin
- Source: Mini Reviews in Medicinal Chemistry, Volume 13, Issue 5, Apr 2013, p. 777 - 782
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- 01 Apr 2013
Abstract
Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeast Hansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (3), in addition to the more polar 3α,4α-dihydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (4). These metabolites were characterized on the basis of their spectral data and the identity of 4 was further confirmed by chemical synthesis.
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