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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV
- Source: Mini Reviews in Medicinal Chemistry, Volume 10, Issue 13, Nov 2010, p. 1277 - 1292
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- 01 Nov 2010
Abstract
CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.
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