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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences
- Source: Mini Reviews in Medicinal Chemistry, Volume 10, Issue 7, Jun 2010, p. 635 - 642
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- 01 Jun 2010
Abstract
Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.
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