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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 14, Dec 2009, p. 1596 - 1604
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- 01 Dec 2009
Abstract
Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
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