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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 8, Jul 2009, p. 984 - 995
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- 01 Jul 2009
Abstract
A concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.
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