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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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New Insights into the Pleiotropic Effects of Statins for Stroke Prevention
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 7, Jun 2009, p. 794 - 804
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- 01 Jun 2009
Abstract
There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - “statins” - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - “pleiotropic” - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.
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