Full text loading...
- ISSN: 1389-5575
- E-ISSN: 1875-5607
-
Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 2, Feb 2009, p. 186 - 193
-
- 01 Feb 2009
Abstract
Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.
© Bentham Science Publishers